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This study recruited healthy volunteers and randomly divided them into four groups. They inhaled oxytocin or saline, and watched a pain test video with photos of acquaintances or strangers, respectively, to test whether their feelings of the same thermal pain stimulus had changed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| OS group | Placebo Comparator | Half an hour after the volunteers inhaled 24 units of oxytocin spray, they watched the pre recorded video (attached with pictures and introductions of strangers) and underwent a pain test. |
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| PS group | Placebo Comparator | Half an hour after the volunteers inhaled the same amount of saline spray, they watched the pre recorded video (with pictures and introductions of strangers attached) and received a pain test. |
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| OA group | Experimental | Half an hour after the volunteers inhaled 24 units of oxytocin spray, they watched the pre recorded video (attached with pictures and introductions of acquaintances) and underwent a pain test. |
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| PA group | Placebo Comparator | Half an hour after the volunteers received the same dose of saline, they watched the pre recorded video (attached with pictures and introductions of acquaintances) and received the pain test. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin nasal spray | Drug | Volunteers inhale 24 units of oxytocin spray |
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| Measure | Description | Time Frame |
|---|---|---|
| NRS score | numerical rating scale of pain， ranging from 0 = "no pain" to 10 = "the most intense pain that is tolerable". | Half an hour after inhaling spray |
| Measure | Description | Time Frame |
|---|---|---|
| EEG | Frequency of electroencephalogram | about 3 hours |
| Brief Profile Of Mood States | Brief Profile Of Mood States is a 30 item self-report psychological instrument intended for use with adults age 18 and above. Response format consisted of the following 5-point Likert scales: 0：not at all; 1：a little; 2：moderately; 3：quite a bit; and 4：extremely. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University People's Hospital | Beijing | Beijing Municipality | 100044 | China |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010468 | Perceptual Disorders |
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| Placebo | Drug | Volunteers inhale 24 units of placebo spray |
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| Stranger | Behavioral | Volunteers watch a video of a pain test and attach a photo of a stranger |
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| Acquaintance | Behavioral | Volunteers watch a video of a pain test and attach a photo of an acquaintance |
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| about 3 hours |
| Beck Depression Inventory | Beck Depression Inventory | about 3 hours |
| WLEIS-C | The English version of the scale was developed by Wong and Law and used as an evaluation tool for emotional intelligence level surveys, the Chinese version of emotional intelligence level consists of 16 items scale (WLEIS-C) , including self-emotional perception (4 items), others' emotional perception (4 items), emotional control (4 items), emotional use (4 items) 4 Dimensions, a total of 16 items. Using Likert 7-level scoring method, '0' stands for 'very disagree' and '6' stands for 'very agree'. The higher the score, the higher the emotional intelligence level. | about 3 hours |
| STAI | state-trait anxiety inventory | about 3 hours |
| BES-C | Chinese version of Basic Empathy Scale.The scale was divided into two dimensions: emotional empathy, which comprised 11 items, and cognitive empathy, which comprised nine items, yielding a total of 20 items (including eight reverse-scoring items). A five-point Likert scale was used, where 1 = "completely disagree" and 5 = "completely agree." A high score indicated strong empathy. | about 3 hours |
| The Positive and Negative Affect Scale | is a 20 item self-report psychological instrument，contains 10 items for positive and 10 items for negative emotions. All the items are rated on a scale ranging from 1 ("very slightly or not at all") to 5 ("extremely"). | about 3 hours |
| NRS score | numerical rating scale of pain， ranging from 0 = "no pain" to 10 = "the most intense pain that is tolerable". | about 3 hours |
| D019954 | Neurobehavioral Manifestations |
| D009422 | Nervous System Diseases |