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This 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the Meridol Base Mouthwash containing 0.2% zinc lactate, 0.17% amine fluoride and 0.0275% sodium fluoride as compared to a Negative Control Mouthwash containing 0.057% sodium fluoride after 3 and 6 months of product use.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.2% zinc lactate, 0.17% amine fluoride and 0.0275% sodium fluoride Mouthwash | Experimental | mouthwash |
|
| 0.057% sodium fluoride Mouthwash | Active Comparator | mouthwash |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0.2% zinc lactate, 0.17% amine fluoride and 0.0275% sodium fluoride Mouthwash | Drug | mouthwash |
|
| Measure | Description | Time Frame |
|---|---|---|
| Gingival inflammation | Loe-Silness Gingival Index | baseline |
| Gingival inflammation | Loe-Silness Gingival Index | 3 months |
| Gingival inflammation | Loe-Silness Gingival Index | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luigi Montesani, MD, DDS | Clinica Odontoiatrica Montesani | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinica Odontoiatrica Montesani | Roma | Rome | 00187 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38217757 | Derived | Montesani L, Montesani L, Mateo L, Daep C, Huber N, Isapour G, Zhang YP. Antibacterial and clinical effectiveness of a mouthwash with a novel active system of amine + zinc lactate + fluoride: a randomized controlled trial. Clin Oral Investig. 2024 Jan 13;28(1):90. doi: 10.1007/s00784-023-05487-0. |
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| ID | Term |
|---|---|
| D058225 | Plaque, Amyloid |
| D005882 | Gingival Diseases |
| ID | Term |
|---|---|
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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| 0.057% sodium fluoride Mouthwash | Drug | mouthwash |
|
| D009057 | Stomatognathic Diseases |