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Background: In recent years, the changes of cognitive function in mild cognitive impairment have attracted attention.
Methods/design: We will follow up at 3. The primary outcome will be the measurement of cognitive function using neuropsychological assessment scales such as MOCA, MMSE, etc... Minor variables will be included plasma biomarkers (Aβ, Tau, GFAP, etc.), multimodal brain electrophysiology (P300, VP300, heart rate variability, etc.), and neuroimaging indicators (NODDI).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy controls without orthostatic hypotension |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| observational study | Other | observational study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Montreal Cognitive Assessment (MoCA) scores after 3 months. | The MOCA scale scores range from 0 to 30, with higher scores indicating better cognition | Participants will be followed up for 3 months after baseline. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Plasma amyloid protein levels after 3 months. | Plasma amyloid protein(ug/ml) is an important indicator of cognitive function. | Participants will be followed up for 3 months after baseline. |
| Changes in Plasma tau levels after 3 months. |
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Inclusion Criteria:
Exclusion Criteria:
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Chinese who met the inclusion and exclusion criteria
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiaodong Pan, Doctor | Contact | 86218341 | pxd77316@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fujian Medical University Union Hospital | Recruiting | Fuzhou | Fujian | 350000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20820000 | Background | Petersen RC, Roberts RO, Knopman DS, Geda YE, Cha RH, Pankratz VS, Boeve BF, Tangalos EG, Ivnik RJ, Rocca WA. Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging. Neurology. 2010 Sep 7;75(10):889-97. doi: 10.1212/WNL.0b013e3181f11d85. | |
| 8208869 | Background | Rabe-Jablonska J, Bienkiewicz W. [Anxiety disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association: diagnostic and statistical manual of mental disorders (DMS-IV -- options book]. Psychiatr Pol. 1994 Mar-Apr;28(2):255-68. Polish. |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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Plasma tau(ug/ml) is an important indicator of cognitive function
| Participants will be followed up for 3 months after baseline. |
| Changes in Blood pressure (mmHg) after 3 months. | An experienced physician will measure blood pressure on the right upper arm after the subject rest for 5 min, taking the average of the two measurements as the final result. | Participants will be followed up for 3 months after baseline. |