Comparison between tamsulosin and Tadalafil in management of benign prostatic hyperplasia A Randomised Trial

Assessment of the discontinuation rate of tamsulosin and tadalafil after 12 months follow up either and evaluate the changes in urinary parameters and sexual parameters in patients with lower urinary tract symptoms due to BPH concomitant with erectile dysfunction. We tried to overcome the limitations of the previous studies by designing a prospective randomized controlled trial as the present study is the first randomized controlled trial that evaluate the safety, discontinuation rate and efficacy of tadalafil compared with tamsulosin for long term follow up (12 months).

Inclusion Criteria:

• patients with Lower Urinary Tract Symptoms
• married and sexually active
• age more than 50 years
• IPSS more than 12
• Q max less than 15 ml/s
• Post voiding residual less than 150 ml

Exclusion Criteria:

• prostatic adenocarcinoma
• cardiac patients on nitrates, patient with unstable angina or recent history of myocardial infarction
• vesical stones
• active Urinary Tract Infection
• patient refused participation in the study