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Cardiac surgery and cardiopulmonary bypass can lead to systemic organ failure trough excess inflammation and endothelial injury. The angiopoietin family represented by angiopoietin 1 and 2 can reflect endothelial injury by a decrease in angiopoietin 1 and an increase in angiopoietin 2. The investigators hypothesized that angiopoietin dysregulation could reflect organ failure related to cardiac surgery.
The purpose of this project is to assess the association between angiopoietin dysregulation and adverse outcomes on cardiac surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cardiac surgery | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sample | Other | 5 ml blood sample will be withdrawn at the surgery start and at the surgery end |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between abnormal angiopoietin 1 concentration (ng/ml) and number of major cardiovascular event | major cardiovascular event are myocardial infraction, stroke, acute kidney injury, cardiovascular death | 28 days |
| correlation between occurence of abnormal angiopoietin 2 concentration (ng/ml) and occurence of major cardiovascular event | major cardiovascular event are myocardial infraction, stroke, acute kidney injury, cardiovascular death | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between abnormal angiopoietin 1 concentration (ng/ml) and number of postoperative pulmonary complications | 28 days | |
| Correlation between abnormal angiopoietin 2 concentration (ng/ml) and number of postoperative pulmonary complications | 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Osama ABOU ARAB, MD | Contact | 03 22 08 78 36 | abouarab.osama@chu-amiens.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens Picardie | Recruiting | Amiens | France |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Correlation between abnormal angiopoietin 1 concentration (ng/ml) and mortality at 3 months | 3 months |
| Correlation between abnormal angiopoietin 2 concentration (ng/ml) and mortality at 3 months | 3 months |
| Correlation between abnormal angiopoietin 1 concentration (ng/ml) and mortality at 6 months | 6 months |
| Correlation between occurence of abnormal angiopoietin 2 concentration (ng/ml) and mortality at 6 months | 6 months |
| Correlation between abnormal angiopoietin 1 concentration (ng/ml) and mortality rate at 12 months | 12 months |
| Correlation between abnormal angiopoietin 2 concentration (ng/ml) and mortality rate at 12 months | 12 months |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |