Next-Generation Sequencing and whole transcriptome RNA sequencing were used to detect genomic variation and expression in tissues or blood, respectively. The treatment outcome of single targeted therapy or combined with immunotherapy was observed and followed up. Through this study, we intend to achieve RNA molecular classification of Chinese mRCC patients and to evaluate the correlation between ctDNA level, RNA molecular classification and treatment outcome, provide reference for metastatic RCC precise diagnosis and treatment.

Inclusion Criteria:

• Clinically diagnosed with renal cell carcinoma confirmed by pathology, including clear renal cell carcinoma and type I papillary renal cell carcinoma, type II papillary renal cell carcinoma, chromophobe renal cell carcinoma and renal cell carcinoma with sarcomatoid differentiation, etc

  • Have distant metastasis
  • metastatic RCC
  • Eastern Cooperative Oncology Group 0 to 1
  • No obvious abnormality was found in blood routine examination, coagulation and liver and kidney function

Exclusion Criteria:

• • Previously received systematic treatment

  • Failure to obtain baseline tumor tissue / blood samples
  • A history of infection with human immunodeficiency virus, or suffer from other acquired and congenital immunodeficiency diseases, or have a history of organ transplantation, or have a history of organ transplantation
  • A history of allergy to disease treatment drugs
  • During lactation or pregnancy