The primary aim of this project is to test if OCOsense glasses can function as a digital phenotyping tool derived from behavioural and physiological signals related to facial expression and motion recorded using the glasses.

Assessment of participants living with a DSM5 research diagnosis of Bipolar disorder or Major depressive disorder as well as healthy controls who will be recruited and characterised through precision phenotyping involving cross-sectional assessment of biobehavioural and physiological markers of the symptoms of depression. Correlations between objective (i.e., OCOsense glasses captured) and subjective (i.e., self-reported) symptoms of depression will be measured within as well as across diagnoses. The resulting biobehavioral clusters will form the building block of a digital phenotyping tool based upon the wider spectrum of non-verbal behaviours and physiology defined and affected by the phenotype of depression.

Inclusion Criteria:

All participants:

• Ability to read & understand English. This is because the majority of our questionnaires are validated in the English language only.
• Able to walk, sit, lay and stand unaided

Clinical cases:

● ≥ 15 on the Patient health Questionnaire-9 (PhQ9) (moderate to severe depression)

Exclusion Criteria:

Healthy control participants:

• Self-reported current or past history (suspected or diagnosed) of any psychiatric condition
• <5 on the Generalised Anxiety Disorder-7 questionnaire (GAD-7)
• <5 on the PhQ-9 (no depression)
• Receiving medication for any psychiatric disorder (excluding fibromyalgia)

All participants:

• < 18 years of age or >40 years of age
• Anatomical constraints that affect fit (e.g. facial disfigurement)
• Facial nerve damage which limits the ability to make facial expressions
• Body Mass Index (BMI) >29.9 which we deem may affect physical mobility

Convenience sampling of young adults.

Where possible, fully anonymised data will be hosted on a secure data responsibility. Specific details will be updated.