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Free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . The donor sites pain , infection and retarded healing by secondary intension are the complication .
After the preparation and characterization of the solid dispersion of hydroxylated methoxy flavones, free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . The donor sites pain , infection and retarded healing by secondary intension are the complications ; the aim of the study is to assess the analgesic , anti inflammatory effects of hydroxylated methoxy flavones.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hydroxylate flavones | Experimental | flavonoids mainly derived from citrus peel and have numerous strong biological activities, including anti-inflammatory , antioxidant , antimicrobial , and anticancer |
|
| alveogyl | Active Comparator | ALVOGYL is a brown fibrous paste which contains per 100 g the following active ingredients : 25.70 g of butamben, 15.80 g of iodoform and 13.70 g of eugenol. |
|
| stent | Placebo Comparator | acrylic resin material used to cover denuded soft tissues |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hydroxylate flavones solid dispersion application | Drug | this drug has the antibacterial and anti inflammatory actions could help the palatal donor sites to promote the wound healing |
| Measure | Description | Time Frame |
|---|---|---|
| post operative pain (VAS scale) | VAS scale from 0 no pain to 10 excruciating pain (healing) | first day postoperative to 30 days (days) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of analgesic and anti inflammatory pills consumed | Minimizing the pain and inflammation during healing process post operative swelling | first day postoperative to 30 days (days) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed Mortada, professor | Contact | 20 0100 543 2223 | mortadafikry@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ahmed Mortada, Professor | Assiut University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut University | Asyut | Egypt |
|
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30794264 | Background | Paolantonio M, De Ninis P, Secondi L, Femminella B. The Full-Thickness Palatal Graft Technique: Description of an Original Surgical Technique and 15 Case Reports. Int J Periodontics Restorative Dent. 2019 Mar/Apr;39(2):267-277. doi: 10.11607/prd.3741. | |
| 24640997 | Background | Zuhr O, Baumer D, Hurzeler M. The addition of soft tissue replacement grafts in plastic periodontal and implant surgery: critical elements in design and execution. J Clin Periodontol. 2014 Apr;41 Suppl 15:S123-42. doi: 10.1111/jcpe.12185. |
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| ID | Term |
|---|---|
| D018461 | Soft Tissue Infections |
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D007239 | Infections |
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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|
| Placebo | Other | Dough inert material without any therapeutic action |
|
| 30152618 | Background | Wyrebek B, Gorski B, Gorska R. Patient morbidity at the palatal donor site depending on gingival graft dimension. Dent Med Probl. 2018 Apr-Jun;55(2):153-159. doi: 10.17219/dmp/91406. |
| 32559041 | Background | Tseng ES, Tavelli L, Wang HL. Palatal Pedicle Flaps for Soft Tissue Augmentation. Int J Periodontics Restorative Dent. 2020 Jul/Aug;40(4):581-588. doi: 10.11607/prd.4561. |
| D009057 |
| Stomatognathic Diseases |
| D055093 | Periodontal Atrophy |