Measurement and Analysis of Gas Composition in Digestive Tract

Measurement and Analysis of Gas Composition in Digestive Tract: a Prospective, Single-center Observational Study

The purpose of this study is to detect the concentration of various gases，including hydrogen, methane, hydrogen sulfide, nitric oxide in different parts of the digestive tract by a safe and direct method, and to establish a human digestive tract gas profiles. Analyze the differences in gas components in different segments of the digestive tract in patients with different diseases, and analyze the correlation between specific gases and digestive tract diseases and non-specific symptoms.

Inclusion Criteria:

• Patients aged 18 to 70 years.
• Patients undergoing endoscopic examination

Exclusion Criteria:

• Patients with serious underlying diseases, such as liver insufficiency, renal insufficiency, immunosuppression, coronary heart disease (angina pectoris or coronary artery stenosis ≥ 75%).
• Patients have history of gastrointestinal surgery
• Patients who failed to complete the endoscopic examination due to various reasons
• Patients Boston score of Bowel preparation≤ 6 points
• Patients who have medication history of probiotics, antibiotics, PPIs and prokinetic drugs in the last 4 weeks
• Patients who combined with thyroid disease and other diseases that affect gastrointestinal motility
• Patients who combined with other risk factors such as mental illness, alcoholism, and drug abuse
• Patients who unable or unwilling to provide informed consent