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| ID | Type | Description | Link |
|---|---|---|---|
| 2022-00980 | Other Grant/Funding Number | Swedish Research Council |
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| Name | Class |
|---|---|
| The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS) | OTHER_GOV |
| The Swedish Research Council | OTHER_GOV |
| Statistics Sweden | UNKNOWN |
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The aim of the project is to assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register study.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Per- and polyfluoroalkyl substances (PFAS) | Other | Assess the association between exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water in pregnancy and birth outcomes (i.e. growth retardation, premature birth, and congenital developmental defects) and maternal morbidity (gestational hypertension, diabetes and preeclampsia) in a prospective population-wide register based cohort. |
| Measure | Description | Time Frame |
|---|---|---|
| Birth outcome - birthweight | grams as measured at birth | at birth |
| Birth outcome - Small for gestational age (SGA) | <-2 standard deviations (SD) from the average weight at the gestational age and sex at partus (Marsal et al. 1996. Acta Paediatr 85(7): 843-848) | at birth |
| Birth outcome - Large for gestational age (LGA) | >2 standard deviations (SD) from the average weight at the gestational age and sex at partus (Marsal et al. 1996. Acta Paediatr 85(7): 843-848) | at birth |
| Birth outcome - major congenital malformations | ICD10- codes: Q00-Q99 within the first 28 days postpartum, categorized as major congenital malformations according to European Surveillance of Congenital Anomalies (EUROCAT 2014) | at birth |
| Maternal health - Gestational hypertension/preeclampsia | ICD10-codes: O13-O14. Diagnosis at maternal or primary care | during gestation |
| Maternal health - Gestational diabetes mellus | ICD10-codes: O24 (excluding pregestational diabetes). Diagnosis at maternal or primary care | during gestation |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant women residing in Swedish localities with a population exceeding 10,000 inhabitants and giving birth during 2012-2018, where PFAS exposure data is available.
IPD is available from registers at Statistics Sweden and National Board of Health and Welfare in Sweden.
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| National Board of Health and Welfare, Sweden |
| OTHER_GOV |
| Swedish University of Agricultural Sciences | OTHER |
| Swedish Food Agency | UNKNOWN |
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| ID | Term |
|---|---|
| D001724 | Birth Weight |
| D016640 | Diabetes, Gestational |
| D046110 | Hypertension, Pregnancy-Induced |
| D011225 | Pre-Eclampsia |
| D000013 | Congenital Abnormalities |
| ID | Term |
|---|---|
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| ID | Term |
|---|---|
| D005466 | Fluorocarbons |
| ID | Term |
|---|---|
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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