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The purpose of this study is to learn more about reproductive hormones and if they change in response to 5-days eating an individualized, standardized diet at two levels: energy balance and low energy intake.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Energy balanced metabolic diet (5-days) | Active Comparator | 45 kcals/kg of fat free mass [FFM]/day; 28% fat, 15% protein, 57% carbohydrate |
|
| Low energy availability metabolic diet (5-days) | Experimental | 20 kcal/kg of FFM/day; 28% fat, 15% protein, 57% carbohydrate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 5-day controlled metabolic dietary intake | Behavioral | Over 5-days, all food will be provided from the metabolic kitchen and participants will be instructed to eat all of the food provided each day and only the food provided each day. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in stimulated pituitary function, as measured by Luteinizing hormone (LH) area under the curve (AUC) over two hours following pituitary stimulation with a physiologic bolus intravenous dose of gonadorelin acetate | Within-participant changes in response to both conditions will be measured, with lower LH AUC indicating a blunted pituitary response to stimulation. | Baseline, ~4-weeks, ~8-weeks (visits timed to to days 1-5 of the menstrual cycle) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Trish Coordinator, MS, RD | Contact | 303-724-6821 | HoWL@cuanschutz.edu |
| Name | Affiliation | Role |
|---|---|---|
| Ann E Caldwell, PhD | University of Colorado Anschutz School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Anschutz Medical Campus | Recruiting | Aurora | Colorado | 80045 | United States |
Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices).
Beginning 3 months after publication. No end date.
Researchers who provide a methodologically sound proposal.
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| ID | Term |
|---|---|
| D007006 | Hypogonadism |
| ID | Term |
|---|---|
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
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