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| ID | Type | Description | Link |
|---|---|---|---|
| 2022-A01998-35 | Other Identifier | ANSM |
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| Name | Class |
|---|---|
| Institut National de Recherche en Informatique et en Automatique | OTHER |
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Parkinson's disease (PD) is the second most common neurodegenerative disease. Multiple system atrophy (MSA) is a relentlessly progressing rare neurodegenerative disease of unknown etiology. The differential diagnosis between the MSA-Parkinsonism (MSA-P) subtype and PD can be very challenging in early disease stages, while early diagnostic certitude is important for the patient because of the diverging prognosis. At the time being, there exists no validated objective biomarker to guide the clinician. Dysarthria is a common early symptom in both diseases and of different origin. The ambition and the originality of this project are to develop a digital voice-based tool for objective discrimination between PD and MSA-P.
The team will build a corpus of voice samples of patients with both diseases and healthy volunteers. This corpus will consist of sustained vowels, pseudo-words, repetition of syllables, utterances of a standard text and spontaneous speech. Voice recordings will be performed using a high quality digital recorder (H4n) and the EVA-2 workstations. EVA-2 is a state-of-the-art system dedicated to pathological voice recording and analysis, which also allows the measurement of aerodynamic features such as intra-oral and subglottal pressure.
An electroglottograph (EGG), a non-invasive device, will also be used in conjunction with the recordings to provide the ground truth of glottal opening and closure instants (OGI and GCI) during utterances. The use of an EGG can be very useful given that OGI and GCI provide valuable information about the voice short-time dynamics.
The team will also perform a laryngostroboscopic examination to highlight defects in vocal cord mobility, a defect in vocal cord mating in phonation, abnormal vocal cord movements or supraglottic structures.
The primary objective is to compare a global score assessing vocal performance between MSA-P, PD and healthy volunteers. Secondary objectives are 1) to compare an acoustic index, assessing the subsystems of speech production, between MSA-P, PD and healthy volunteers, 2) to compare an acoustic index, assessing types of dysarthria, between MSA-P and PD patients, and 3) to compare perceptual assessment, performed by a panel of experts, of voice alteration between MSA-P and PD patients.
The final goal of this study is to evaluate the validity of the vocal markers that were identified in the previous study (Voice4PD-MSA-I, exploratory cohort). The validation will only consider data collected in the present study in order to assess the performance of the classifiers developed in the exploratory cohort.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parkinson's disease | Experimental | Diagnosis of idiopathic Parkinson's disease (PD) according to MDS criteria (Postuma et al., 2015) |
|
| Multiple system atrophy parkinsonian subtype (MSA-P) | Experimental | Diagnosis of Multiple Atrophy System (MSA-P) Parkinsonian form possible or probable according to consensus criteria (Gilman et al., 2008) |
|
| Healthy volunteer | Experimental | Absence of neurologic and oto-rhino-laryngologic disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| voice recordings | Procedure | A digital processing of voice recordings (from 30 to 45 minutes) will be performed for each participant, using a high quality digital recorder: the DIANA (computerized device of acoustic analysis) and the EVA-2 workstations (assisted Evaluation system Voice) |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of global vocal performance score based on six acoustic components | 1. Differences between groups (PD, MSA-P, and controls) in global vocal performance score based on six acoustic components (1. Incoordination of articulatory movements: TDV (pseudowords), 2. Difficulty initiating movements: VOT (diadochokinesis), DPI (reading text and monologue), 3. Hyperkinetic movements: stdF0, stdPSD, DVA (held vowel /a/), 4. Reduced range of motion: stdF0 (read text and monologue), 5. Slowness of movement: NSR (read text), DDKR (diadochokinesis), VD (diadochokinesis), and 6. Irregularity of movements: DDKI (diadochokinesis)). | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| measurements of a composite acoustic index assessing speech production subsystems | Differences between groups (PD, MSA-P, and controls) in a composite acoustic index, assessing speech production subsystems. The acoustic index will be calculated by linear combinations, described in [Daoudi et al., 2022], of features evaluating the performance of subsystems of speech production: breathing, phonation, articulation, prosody and timing. |
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Inclusion criteria:
Age from 30 to 80 years old
Signed informed consent
Affiliated to social security
Patient with PD :
Patients with MSA-P :
Controls :
Exclusion criteria :
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| Name | Affiliation | Role |
|---|---|---|
| Wassilios MEISSNER, MD, PhD | University Hospital, Bordeaux | Principal Investigator |
| Khalid DAOUDI, PhD | nstitut National de Recherche en Informatique et en Automatique | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Bordeaux - Institut des maladies neurodégénératives de Bordeaux | Bordeaux | 33000 | France | |||
| Centre Hospitalier Universitaire de Toulouse |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | Khalid Daoudi, Farouk Yahaya, Solange Milhé de Saint Victor, Alexandra Foubert-Samier, Margherita Fabbri, et al.. Speech glottal flow performance in early stages of Parkinson's disease and multiple systems atrophy. 2025. ⟨hal-05356075⟩ | ||
| Result | Khalid Daoudi (1) , Farouk Yahaya (1) , Solange Milhé de Saint Victor (2) , Alexandra Foubert-Samier (3) , Margherita Fabbri (4) , Anne Pavy-Le Traon (4) , Olivier Rascol (4) , Clémence Devoucoux (5) , Virginie Woisard (5) , Wassilios G. Meissner (3) ; Speech glottal flow performance in early stages of Parkinson's disease and multiple systems atrophy ; Preprint submitted to Elsevier on 10 Nov 2025 ; HAL Id: hal-05356075 |
| Label | URL |
|---|---|
| INRIA Portal for citation | View source |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D019578 | Multiple System Atrophy |
| D004401 | Dysarthria |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Day 1 |
| measurements of a composite acoustic index assessing hypokinetic, ataxic and spastic dysarthria | Differences between groups (PD and MSA-P) in a composite acoustic index assessing hypokinetic, ataxic and spastic dysarthria. The acoustic index will be calculated by linear combinations, described in [Daoudi et al., 2022], of features assessing hypokinetic, ataxic and spastic dysarthria. | Day 1 |
| measurements of a vocal impairment score based on perceptual assessment by an expert jury (Range 1-10) | Differences between groups (PD and MSA-P) in a vocal impairment score based on perceptual assessment by an expert jury (Range 1-10). The score between 1 (for inaudible voice) and 10 (for normal voice) is calculated by averaging the sub-scores (between 1 and 10) evaluating intelligibility, articulation, prosody and resonance. | Day 1 |
| Toulouse |
| 31000 |
| France |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D054969 | Primary Dysautonomias |
| D001342 | Autonomic Nervous System Diseases |
| D001184 | Articulation Disorders |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |