The Effect of Dorsal Genital Nerve Stimulation on Opening Urethral Pressure

The Effect of Dorsal Genital Nerve Stimulation on Opening Urethral Pressure

This study aims to investigate the effect of electrical stimulation of the dorsal genital nerve on the urethral pressure in healthy women.

Inclusion Criteria:

• Normal weight (Body weight 50 kg or more, Body Mass Index 18-5-30 kg/m2)
• Signed an informed consent

Exclusion Criteria:

Any history of clinically significant diseases, unless regarded irrelevant and/or stable by the investigator

• Any history or evidence of clinically significant urinary incontinence, urinary retention, overactive bladder, or other voiding dysfunction
• Known or suspected nerve injuries or paraesthesia in the pelvic area
• Pregnancy within six months before enrolment
• Breastfeeding within three months before enrolment
• Smoking or other regular use of any form of nicotine product during the study period and the previous 3 months
• Current or prior participation (within 3 months before screening) in other clinical trials that might affect the results of this study (judged by the investigator)
• Any systemic drug use within 2 weeks before the first study day (prescription drugs, over-the-counter drugs, herbal drugs, and/or illicit drugs), except for occasional use of paracetamol (up to 4 g/day), ibuprofen, or antihistamine, hormonal contraceptives and hormone replacement therapy.