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| Name | Class |
|---|---|
| Fondazione Italiana Linfomi | UNKNOWN |
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This is an observational retrospective and prospective multicenter study aimed at describing the role of the COVID -19 prophylaxis with Tixagevimab and Cilgavimab in CLL or indolent B-NHL patients who received first COVID-19 prophylaxis dose between March 2022 and October 2022.
This is an observational retrospective and prospective multicenter study aimed at describing the role of the COVID -19 prophylaxis with Tixagevimab and Cilgavimab in CLL or indolent B-NHL patients.
All CLL or indolent B-cell NHL patients (follicular lymphoma, marginal zone lymphoma, lymphoplasmacytic lymphoma) who received first COVID-19 prophylaxis dose with Tixagevimab and Cilgavimab according to AIFA indication between March 2022 and October 2022 will be included in the study.
Each patient will be followed for a maximum of 12 months from the first COVID-19 prophylaxis dose.
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| Measure | Description | Time Frame |
|---|---|---|
| Assess the percentage of patients who develop severe COVID-19 infection | Evaluation of prophylaxis efficacy in terms of percentage of patients with CLL or indolent B-NHL who develop severe COVID-19 infection, defined as COVID-19-related hospitalization or COVID -19 related death | at 12 months |
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Inclusion Criteria:
Exclusion Criteria:
None
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Patients with CLL or indolent B-NHL (follicular lymphoma, marginal zone lymphoma, lymphoplasmacytic lymphoma) who received the Tixagevimab and Cilgavimab as per Agenzia Italiana del Farmaco (AIFA) indications.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Paola Fazi | Contact | 0670390528 | p.fazi@gimema.it | |
| Enrico Crea | Contact | 0670390514 | e.crea@gimema.it |
| Name | Affiliation | Role |
|---|---|---|
| Gian Matteo Rigolin | Ematologia - Azienda Ospedaliero Universitaria S.Anna di Ferrara | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UOC Ematologia AO Cosenza | Recruiting | Cosenza | Italy |
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| Ematologia AOU S.Anna | Recruiting | Ferrara | Italy |
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| Ematologia AOU Careggi | Recruiting | Florence | Italy |
|
| ASST Lecco Ospedale A.Manzoni | Recruiting | Lecco | Italy |
|
| UOC Ematologia ATMO | Recruiting | Livorno | Italy |
|
| ASST Grande Ospedale Metropolitano Niguarda | Recruiting | Milan | Italy |
|
| SCDU Ematologia | Recruiting | Novara | Italy |
|
| Dipartimento Oncologico La Maddalena | Recruiting | Palermo | Italy |
|
| UOC DI ONCOEMATOLOGIA AOR Villa Sofia - Cervello | Recruiting | Palermo | Italy |
|
| Ematologia Università "Sapienza" Roma | Recruiting | Roma | Italy |
|
| IRCCS Istituto Clinico Humanitas | Recruiting | Rozzano | Italy |
|
| UOC Ematologia Casa Sollievo della Sofferenza | Recruiting | San Giovanni Rotondo | Italy |
|
| SCDU Ematologia e terapie cellulari AO Mauriziano | Recruiting | Torino | Italy |
|
| Ematologia Ospedale S.Chiara | Recruiting | Trento | Italy |
|
| UOC ematologia ULSS2 Marca Trevigiana | Recruiting | Treviso | Italy |
|
| ID | Term |
|---|---|
| D015451 | Leukemia, Lymphocytic, Chronic, B-Cell |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D015448 | Leukemia, B-Cell |
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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