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| Name | Class |
|---|---|
| Göteborg University | OTHER |
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Early detection of bladder cancer (BCa) is considered an effective strategy to curb mortality from the disease. However, current urinary biomarkers have insufficient specificity to warrant BCa screening. Urine free glycosaminoglycan profiles (or GAGomes) are promising noninvasive biomarkers of cancer metabolism. In this study, samples are obtained from patients with BCa and controls to compare the glycosaminoglycan profiles between groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bladder cancer |
| ||
| No evidence of disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Free glycosaminoglycan profiling | Diagnostic Test | Free glycosaminoglycan profiling (GAGome) analysis was performed at a single blinded central laboratory using commercial kits wherein the concentration (in µg/mL) of 17 chondroitin sulfate (CS), heparan sulfate (HS), hyaluronic acid (HA) disaccharides were detected and quantified using a UHPLC-MS/MS system. |
| Measure | Description | Time Frame |
|---|---|---|
| Area-under-the-receiving operating characteristic (ROC)-curve (AUC) for the classification of BCa versus NED | Before primary surgery for BCa; at a post-surgical follow-up visit for controls up to 5 years from primary surgery |
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Cases (Bladder cancer [BCa])
Inclusion Criteria:
Exclusion Criteria:
Controls (No evidence of disease [NED])
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Exclusion Criteria:
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Prospective case-control study to compare patients elected for transurethral resection of the bladder (TURB) for bladder cancer (BCa) [cases] versus patients with no evidence of disease (NED) during the follow-up of previously localised BCa [controls].
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Urology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg | Gothenburg | Sweden |
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| ID | Term |
|---|---|
| D001749 | Urinary Bladder Neoplasms |
| ID | Term |
|---|---|
| D014571 | Urologic Neoplasms |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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|
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D001745 | Urinary Bladder Diseases |
| D014570 | Urologic Diseases |
| D052801 | Male Urogenital Diseases |