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| Name | Class |
|---|---|
| Centre d'Epidémiologie et de Santé Publique des Armées | UNKNOWN |
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Toxigenic cutaneous diphtheria is a notifiable disease that is re-emerging in the world and particularly in France. A better description of the epidemiological characteristics, as well as a refinement of the clinical characteristics of patients with cutaneous diphtheria, are essential to better understand this pathology, which has important public health issues and whose diagnosis absence can have catastrophic consequences for the patient and their contacts. Microbiological data (species identification, toxigenicity or not, resistance profile...) will be transmitted by the national reference center for corynebacteria of the diphtheriae complex and then caregivers who have managed the corresponding patients with cutaneous diphtheria will be contacted.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with cutaneous diphteria | The study group consists of all the patients suffering from cutaneous diphtheria in metropolitan France and for which microbiological data were registered by the National Reference Center fo corynebacteria of the diphteriae complex between 2018 and 2022. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Characteristics description | Other | Caregivers who follow the patients of the study group will be contacted to collect these patients clinical and epidemiological characteristics |
|
| Measure | Description | Time Frame |
|---|---|---|
| Patients epidemiological data description | Epidemiological data will be collected to describe the studied population (age, sex, place of birth, vaccination status...) | 3 months |
| Patients clinical data description | Clinical data will be collected to describe the studied population (history, description of lesions, disease evolution, complications...) | 3 months |
| Patients microbiological data description | Microbiological data will be collected to describe the studied population (species identification, toxigenicity, presence of a co-infection...) | 3 months |
| Patients therapeutic data description | Therapeutic data will be collected to describe the studied population (antibiotic therapy, duration of treatment, search for an eradication a posteriori...) | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of antibiotic therapy duration to national recommendations issued by the High Committee of Public Health | Duration of antibiotic therapy implemented by clinicians will be compared to national recommendations | 3 months |
| Comparison of immunization status monitoring to national recommendations issued by the High Committee of Public Health |
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Inclusion Criteria:
Exclusion Criteria:
- Patient opposition
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Study population corresponds to all metropolitan French patients suffering from cutaneous diphtheria for which microbiological data were registered between 2018 and 2022 by the National Reference Center for corynebacteria of the diphteriae complex.
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| Name | Affiliation | Role |
|---|---|---|
| Fabien DUTASTA, MD | SSA | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut Hospitalo-Universitaire de Marseille | Marseille | Bouches-du-Rhône | 13005 | France | ||
| CHU de Dijon |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31755876 | Background | Bernard KA, Pacheco AL, Burdz T, Wiebe D. Increase in detection of Corynebacterium diphtheriae in Canada: 2006-2019. Can Commun Dis Rep. 2019 Nov 7;45(11):296-301. doi: 10.14745/ccdr.v45i11a04. eCollection 2019 Nov 7. | |
| 31418673 | Background | Martini H, Soetens O, Litt D, Fry NK, Detemmerman L, Wybo I, Desombere I, Efstratiou A, Pierard D. Diphtheria in Belgium: 2010-2017. J Med Microbiol. 2019 Oct;68(10):1517-1525. doi: 10.1099/jmm.0.001039. |
| Label | URL |
|---|---|
| Related Info | View source |
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Monitoring of immunization status or not will be collected |
| 3 months |
| Comparison of patient post infection vaccination status to national recommendations issued by the High Committee of Public Health | Post-infection vaccination or not will be collected | 3 months |
| Comparison of patient microbiological follow-up to national recommendations issued by the High Committee of Public Health | Microbiological follow-up with eradication research or not will be collected. | 3 months |
| Comparison of post-infection serological sampling to national recommendations issued by the High Committee of Public Health | Whether a post-infection serological sampling was performed or not will be collected. | 3 months |
| Comparison of patient isolation procedures to national recommendations issued by the High Committee of Public Health | Patient isolation or not will be collected. | 3 months |
| Dijon |
| Bourgogne-Franche-Comté |
| 21079 |
| France |
| CHU de Caen | Caen | Calvados | 14000 | France |
| Centre Hospitalier de Brive | Brive-la-Gaillarde | Corrèze | 19100 | France |
| Centre Hospitalier de Guingamp | Pabu | Côtes d'Armor | 22205 | France |
| Centre Hospitalier Sud Francilien | Corbeil-Essonnes | Essonne | 91100 | France |
| CHU Bordeaux | Bordeaux | Gironde | 33000 | France |
| Hôpital Louis Pasteur (HCC) | Colmar | Haut-Rhin | 68024 | France |
| Centre Hospitalier Alpes-Leman CHAL | Contamine-sur-Arve | Haute-Savoie | 74130 | France |
| Centre Hospitalier de Briançon | Briançon | Hautes-Alpes | 05100 | France |
| Centre Hospitalier de Lourdes | Lourdes | Hautes-Pyrénées | 65107 | France |
| Hôpital Ambroise Paré (AP-HP) | Boulogne-Billancourt | Hauts-de-Seine | 92100 | France |
| Hôpital Américain de Paris | Neuilly-sur-Seine | Hauts-de-Seine | 92200 | France |
| CHU de Montpellier | Montpellier | Hérault | 34295 | France |
| CHRU de Tours | Chambray-lès-Tours | Indre-et-Loire | 37170 | France |
| Groupement Hospitalier Nord Dauphiné | Bourgoin | Isère | 38300 | France |
| CHU de Nantes | Nantes | Loire-Atlantique | 44000 | France |
| Centre Hospitalier Régional d'Orléans | Orléans | Loiret | 45067 | France |
| Centre Hospitalier de Cahors | Cahors | Lot | 46005 | France |
| Centre Hospitalier Cholet | Cholet | Maine-et-Loire | 49300 | France |
| Centre Hospitalier de Saint-Lo | Saint-Lô | Manche | 50000 | France |
| CHU de Lille | Lille | Nord | 59037 | France |
| Centre Hospitalier de Valenciennes | Valenciennes | Nord | 59300 | France |
| CHU de Saint-Etienne | Saint-Priest-en-Jarez | Pays de la Loire Region | 42270 | France |
| Centre d'endocrinologie | Cabestany | Pyrénées Orientales | 66300 | France |
| Hôpital Edouard Herriot (HCL) | Lyon | Rhône | 69003 | France |
| Hôpital Croix rousse (HCL) | Lyon | Rhône | 69004 | France |
| Centre Hospitalier William Morey | Chalon-sur-Saône | Saône-et-Loire | 71321 | France |
| Centre Hospitalier de Mâcon | Mâcon | Saône-et-Loire | 71000 | France |
| Hôpital Avicenne Bobigny (AP-HP) | Bobigny | Seine-Saint-Denis | 93000 | France |
| CHU d'Amiens | Amiens | Somme | 80054 | France |
| Hôpital Nord Franche-Comté | Trévenans | Territoire De Belfort | 90400 | France |
| Hôpital Henri Mondor (AP-HP) | Créteil | Val-de-Marne | 94000 | France |
| HIA Sainte Anne | Toulon | VAR | 83000 | France |
| Centre Hospitalier d'Avignon | Avignon | Vaucluse | 84000 | France |
| Centre Hospitalier Départemental de Vendée | La Roche-sur-Yon | Vendée | 85000 | France |
| Hôpital Saint Joseph | Paris | 13008 | France |
| Hôpital Saint Louis | Paris | 75010 | France |
| Hôpital Saint Antoine | Paris | 75012 | France |
| Hôpital La Pitié Salpêtrière | Paris | 75013 | France |
| Groupement Hospitalier Diaconesses Croix Saint Simon | Paris | 75020 | France |
| CHU de Toulouse - Hôpital La Grave | Toulouse | 31300 | France |
| 27263151 | Background | Jaton L, Kritikos A, Bodenmann P, Greub G, Merz L. [European migrant crisis and reemergence of infections in Switzerland]. Rev Med Suisse. 2016 Apr 13;12(514):749-53. French. |
| 29282460 | Background | Morgado-Carrasco D, Riquelme-Mc Loughlin C, Fusta-Novell X, Fernandez-Pittol MJ, Bosch J, Mascaro JM Jr. Cutaneous Diphtheria Mimicking Pyoderma Gangrenosum. JAMA Dermatol. 2018 Feb 1;154(2):227-228. doi: 10.1001/jamadermatol.2017.4786. No abstract available. |
| 10321948 | Background | Pandit N, Yeshwanth M. Cutaneous diphtheria in a child. Int J Dermatol. 1999 Apr;38(4):298-9. doi: 10.1046/j.1365-4362.1999.00658.x. No abstract available. |
| 22304732 | Background | Wagner KS, White JM, Lucenko I, Mercer D, Crowcroft NS, Neal S, Efstratiou A; Diphtheria Surveillance Network. Diphtheria in the postepidemic period, Europe, 2000-2009. Emerg Infect Dis. 2012 Feb;18(2):217-25. doi: 10.3201/eid1802.110987. |
| 32209165 | Background | Gower CM, Scobie A, Fry NK, Litt DJ, Cameron JC, Chand MA, Brown CS, Collins S, White JM, Ramsay ME, Amirthalingam G. The changing epidemiology of diphtheria in the United Kingdom, 2009 to 2017. Euro Surveill. 2020 Mar;25(11):1900462. doi: 10.2807/1560-7917.ES.2020.25.11.1900462. |
| 805182 | Background | Koopman JS, Campbell J. The role of cutaneous diphtheria infections in a diphtheria epidemic. J Infect Dis. 1975 Mar;131(3):239-44. doi: 10.1093/infdis/131.3.239. |
| 15109425 | Background | de Benoist AC, White JM, Efstratiou A, Kelly C, Mann G, Nazareth B, Irish CJ, Kumar D, Crowcroft NS. Imported cutaneous diphtheria, United Kingdom. Emerg Infect Dis. 2004 Mar;10(3):511-3. doi: 10.3201/eid1003.030524. |
| 39324172 | Result | Chene L, Morand JJ, Badell E, Toubiana J, Janvier F, Marthinet H, Suppini JP, Valois A, Texier G, Brisse S, Dutasta F OEDIPE Study Group. Cutaneous diphtheria from 2018 to 2022: an observational, retrospective study of epidemiological, microbiological, clinical, and therapeutic characteristics in metropolitan France. Emerg Microbes Infect. 2024 Dec;13(1):2408324. doi: 10.1080/22221751.2024.2408324. Epub 2024 Sep 30. |
| Related Info | View source |
| ID | Term |
|---|---|
| D004165 | Diphtheria |
| ID | Term |
|---|---|
| D003354 | Corynebacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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