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The goal of this type of clinical trial is to learn about symptomatic patients with post-COVID-19 parenchymal lung abnormalities. The main questions it aims to answer are: the efficacy and safety of low-dose dexamethasone or traditional Chinese medicine in symptomatic patients with post-COVID-19 parenchymal lung abnormalities.
Participants will be divided into three parallel groups:controlled group with conventional western medicine treatment including oxygen therapy, antibiotics, nebulization therapy, etc. dexamethasone group: dexamethasone 1.5mg/day for one week and 0.75mg/day for another week basing on conventional western medicine. Chinese medicine group: Strengthening spleen and tonifying lung decoction for 2 weeks basing on conventional western medicine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| controlled group | Active Comparator | conventional western medicine treatment including oxygen therapy, antibiotics, nebulization therapy, etc. |
|
| dexamethasone group | Experimental | dexamethasone 1.5mg/day for one week and 0.75mg/day for another week basing on conventional western medicine. |
|
| Chinese medicine group | Experimental | Strengthening spleen and tonifying lung decoction for 2 weeks basing on conventional western medicine. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| conventional western medicine treatment | Other | conventional western medicine treatment only |
|
| Measure | Description | Time Frame |
|---|---|---|
| Lung CT scan | compared with base,≥90% pneumonia obsorbed | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Lung CT scan | compared with base,≥50% pneumonia obsorbed | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wanmu Xie, Doctor | Contact | 86-10-84206246 | xiewanmu@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Zhenguo Zhai, Dcotor | Department of Respiratory and Critical Care Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China-Japan Friendship Hospital | Recruiting | Beijing | Beijing Municipality | 100029 | China |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| Dexamethasone oral tablet | Drug | treat with Dexamethasone for 2 weeks |
|
| Traditional Chinese medicine decoction | Other | treat with strengthening spleen and tonifying lung decoction for 2 weeks |
|
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |