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| Name | Class |
|---|---|
| Josip Juraj Strossmayer University of Osijek | OTHER |
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The aim of this study was to measure whether the flow rate through the brachial artery and inflammatory markers were associated with the development of tissue edema in the surgical intensive care unit patients.
The study was performed using a ultrasound machine with linear probe settings at 50 mm depth and 40 decibel [dB] gain that did not change during the study. The probe was placed on vascular ultrasound measurement. The diameter of the brachial artery in the middle of the upper arm and the flow rate through the artery was measured on postoperative days 1 and 2. The presence of the edema was measured above the 3rd metacarpal bone as the distance from the skin surface to the periosteum. An average of three assessments was shown. Patient's age, body mass index (BMI), type of admission, white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were also registered.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICU patients | Adult patients admitted to the ICU. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound measurement | Diagnostic Test | Study was conducted with Mindray T7 ultrasound machine using linear probe. Vascular ultrasound mode was used with settings depth of 50 mm and gain of 40 dB during the entire study period. The diameter and flow velocity of the brachial artery and wrist edema of the fist were measured within 24 hours of admission and the following day. |
| Measure | Description | Time Frame |
|---|---|---|
| Diameter of brachial artery - 1 | Measurement of a brachial artery diameter [cm] at admission. Admission day is considered as day 1. | within 4 hours of admission. |
| Diameter of brachial artery - 2 | measurement of a brachial artery diameter [cm] on day 2 after admission. | day 2 after admission is between 24 and 48 hours after admission. |
| Brachial artery flow velocity - 1 | measurement of a brachial artery flow velocity [cm/s] at admission. | within 4 hours of admission to ICU. |
| Brachial artery flow velocity - 2 | measurement of a brachial artery flow velocity [cm/s] on day 2 after admission. Day 2 is Measurement of a brachial artery flow velocity [cm/s] between 24 and 48 h after ICU admission. | day 2 after admission is between 24 and 48 hours after admission. |
| Distance from skin to third metacarpal bone -1 | measurement of a distance from the skin to third metacarpal bone (cm) at admission. | within 4 hours of admission. |
| Distance from skin to third metacarpal bone - 2 | measurement of a distance from the skin to third metacarpal bone (cm) on day 2 after admission. | day 2 after admission is between 24 and 48 hours after admission. |
| White blood cell count - 1 | blood sample analysis for white blood cell count (WBC [10^9/L]) at admission. |
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Inclusion Criteria:
Exclusion Criteria:
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The patients in Osijek University Hospital who are admitted in the ICU will be included in the study.
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| Name | Affiliation | Role |
|---|---|---|
| Slavica Kvolik, M.D., PhD, | Osijek University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Slavica Kvolik | Osijek | 31000 | Croatia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Chakraborty RK, Burns B. Systemic Inflammatory Response Syndrome. [Updated 2021 Jul 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547669/ | ||
| Background | Čavka A, Tadžić R, Grizelj I, Unfirer S, Mihaljević Z, Mihalj M et al. Endotelna funkcija - funkcionalni pokazatelj kardiovaskularnih rizičnih čimbenika. Medicinski vjesnik [Internet]. 2012 [Accessed 23.05.2021.];44((1-4)):135-146. Available from: https://hrcak.srce.hr/187756 | ||
| 21733876 | Background | Lu D, Kassab GS. Role of shear stress and stretch in vascular mechanobiology. J R Soc Interface. 2011 Oct 7;8(63):1379-85. doi: 10.1098/rsif.2011.0177. Epub 2011 Jul 6. | |
| 29467962 |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| within 4 hours of admission. |
| White blood cell count - 2 | blood sample analysis for white blood cell count (WBC [10^9/L]) on day 2 after admission. | day 2 after admission is between 24 and 48 hours after admission. |
| C-reactive protein - 1 | blood sample analysis for C-reactive protein (CRP [mg/L]) concentration at admission. | within 4 hours of admission. |
| C-reactive protein - 2 | Blood sample analysis for C-reactive protein (CRP [mg/L]) concentration on day 2 after admission. | day 2 after admission is between 24 and 48 hours after admission. |
| Procalcitonin - 1 | blood sample analysis for Procalcitonin concentration (PCT [ug/L]) at admission. | within 4 hours of admission. |
| Procalcitonin - 2 | Blood sample analysis for Procalcitonin concentration (PCT [ug/L]) on day 2 after admission. | Day 2 after admission is between 24 and 48 hours after admission. |
| Background |
| Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. eCollection 2018 Jan 23. |
| 30356867 | Background | Mortaz E, Alipoor SD, Adcock IM, Mumby S, Koenderman L. Update on Neutrophil Function in Severe Inflammation. Front Immunol. 2018 Oct 2;9:2171. doi: 10.3389/fimmu.2018.02171. eCollection 2018. |
| 29706967 | Background | Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018 Apr 13;9:754. doi: 10.3389/fimmu.2018.00754. eCollection 2018. |
| 20349817 | Background | Evans DH. Colour flow and motion imaging. Proc Inst Mech Eng H. 2010;224(2):241-53. doi: 10.1243/09544119JEIM599. |
| 23727991 | Background | Kubler A, Maciejewski D, Adamik B, Kaczorowska M. Mechanical ventilation in ICUs in Poland: a multi-center point-prevalence study. Med Sci Monit. 2013 Jun 3;19:424-9. doi: 10.12659/MSM.883930. |