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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
| Nottingham University Hospitals NHS Trust | OTHER |
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Sarcopenia characterised by loss of muscle mass, muscle strength and physical performance burdens many older adults since the condition is related to functional decline. Periods of inactivity such as during hospitalisation leads to further functional decline. It has been reported that the loss of muscle mass associated with sarcopenia not only entails a decrease in muscle mass but also changes in muscle architecture. Knowledge on changes in muscle architecture is essential since it is one of the most important determinants on muscle strength and thus physical performance. The main objective of this study is to investigate changes in muscle architecture and physical performance during acute hospitalisation and after discharge in older adults and subsequently the effectiveness of resistance training of the lower limb during acute hospitalisation. If successful, our study could have a great impact on the individual, as well as societal level, due to a better understanding of the factors related to sarcopenia and the prevention of functional decline as a result of hospitalisation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention Group | Experimental | Group of participants receiving resistance training during hospitalisation |
|
| Control Group | Sham Comparator | Group of participants receiving sham training during hospitalisation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance training | Other | Moderate resistance training by a innovative training robot 2 times a day during hospitalisation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline B-mode ultrasonography | Muscle architecture of the m Vastus Lateralis assessed with B-mode ultrasonography. | Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week). |
| Change from baseline 4 meter Gait Speed Test | Physical performance evaluated by the 4m Gait Speed test | Baseline (Day of hospitalisation) to day of discharge from hospital (an average of a week). |
| Change from baseline B-mode ultrasonography | Muscle architecture of the muscle vastus lateralis assessed with B-mode ultrasonography. | Change from baseline (day of hospitalisation) to 1-month follow-up and 3-months follow-up |
| Change from baseline 4 meter Gait Speed Test | Physical performance evaluated by the 4m Gait Speed test | Change from baseline (day of hospitalisation) to 1-month follow-up and 3-months follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline 30s Chair Stand test | Maximal muscle strength of the lower extremities evaluated by the 30s Chair Stand Test or the m30s Chair Stand Test (Modified). | Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week) |
| Change from baseline Barthel-Index 100 (Shahs version) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kristian B Buhl, MD | Department of Geriatric, Odense University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Geriatric Deparment OUH Svendborg Hospital | Svendborg | FYN | 5700 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42347914 | Derived | Phillip JG, Oddsson HR, Ryg J, Suetta C, Masud T, Minet LR. Unraveling physical performance over time in hospitalized older patients with walking limitation: the role of ultrasound-derived vastus lateralis muscle thickness. Geroscience. 2026 Jun 25. doi: 10.1007/s11357-026-02384-8. Online ahead of print. |
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Functional level evaluated by The Barthel-Index 100 (Shahs version) |
| Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week) |
| Change from baseline Bioimpedance | Muscle quantity (kg) on wholebody level evaluated by Bioimpedance | Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week) |
| Length of hospital stay | Number of days hospitalised | Baseline (day of hospitalisation) to day of discharge from hospital (an average of a week) |
| Mortality | Administrative registers will be used to assess mortality | Baseline (day of hospitalization) to 3-months follow-up |
| Unplanned hospitalisation | Patients will be followed through a review of medical records for any unplanned Adminstrative registers will be used to assess any unplanned hospitalisation during the period of inclusion. | Day of discharge from hospital to 3-months follow-up |
| Individual level of physiotherapy | Adminstrative registers and municipalities health records will be used to assess the individual level of physiotherapy (minutes of consultation) in the period of inclusion. | Baseline (day of hospitalisation) to 3-months follow-up |
| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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