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To describe the molecular, electrophysiological and morphological expression profile of dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Skin biopsy | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Skin biopsy | Procedure | Punch biopsy of the skin |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neurophysiological characterization of dopaminergic neurons derived from patients with Parkinson's disease. | To evaluate the firing frequency in the dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease. | Baseline |
| Biochemical characterization of dopaminergic neurons derived from patients with Parkinson's disease. | To determine the amount of dopamine released from differentiated neurons derived from fibroblasts of patients with Parkinson's disease. | Baseline |
| α-synuclein misfolding in dopaminergic neurons derived from patients with Parkinson's disease. | To document the presence of abnormal accumulation of misfolded alpha-synuclein in the dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guido Alessandro Primiano, MD | Contact | +390630156433 | guidoalessandro.primiano@policlinicogemelli.it | |
| Flavia Torlizzi | Contact | 0630156433 | flavia.torlizzi@policlinicogemelli.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Flavia Torlizzi | Recruiting | Roma | 00168 | Italy |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |