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This is a single arm, single centre, investigator initiated study to investigate the feasibility of using PET-MRI imaging in radiation treatment workflow in up to 15 patients with esophagogastric cancer. PET-MRI imaging will be completed before the start of radiation treatment. MRI imaging will be completed during radiation treatment and after radiation treatment. These images will not be used to plan the radiation treatment and routine clinical care will be provided.
The goal of this study is to gather information that will allow the radiation team to include MRI and PET imaging into the radiation treatment workflow for patients with esophageal cancer receiving radiation therapy in the future.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PET-MRI | Experimental | PET-MRI in esophagogastric cancers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PET-MRI | Procedure | A PET/MRI scan is a two-in-one test that combines images from a positron emission tomography (PET) scan and a magnetic resonance imaging (MRI) scan. Magnetic Resonance Imaging (MRI) provides better soft tissue contrast compared to conventional computerized tomography (CT), and when combined with PET, can potentially provide better visualization of the tumor shape, size, and position. Additional MRI imaging will be completed once during radiation treatment, and once after radiation treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of PET-MRI to visualize and assess impact of RT treatments on esophagogastric tumors | Detection of metastases on DWI and gadolinium enhanced T1-weighted 3D VIBE sequences. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in manual GTV segmentation using PET-MRI | Differences in manual GTV segmentation between standard of care treatment plan and study generated treatment plan using PET-MRI. | 2 years |
| Quantification of dosimetric advantages of PET-MRI treatment plan |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rebecca K S Wong, MD | Contact | 4169462000 | 5736 | rebecca.wong@uhn.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Princess Margaret Cancer Centre | Recruiting | Toronto | Ontario | Canada |
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|
Comparison of dosimetry properties between the standard of care treatment plan and study generated treatment plan using PET-MRI. |
| 2 years |