The goal of this prospective study with the aim to establish a registry is to learn about the role of steroid hormones in severely injured patients. The main question it aims to answer is whether steroid hormones influence morbidity and mortality after severe trauma.

This is a prospective study with the aim to establish a large registry for severely injured patients and their hormonal status.

Hormone levels will be measured upon arrival in the emergency room and within the following few days after trauma. Furthermore a detailed questionnaire aims to answer any hormone-related health questions.

Inclusion Criteria:

• Polytrauma with ISS≥16,
• severe traumatic brain injury (AIS ≥3)
• over the age of 18
• must reach emergency room alive

Exclusion Criteria:

• pregnant patients
• dead on arrival to the hospital
• incarcerated patients
• secondarily transferred patients

All patients suffering from severe trauma (ISS ≥ 16) or severe traumatic brain injury (AIS ≥3) will be enrolled in this study.