Antithrombin to Improve Thromboprophylaxis and Reduce the Incidence of Trauma-Related Venous Thromboembolism

Antithrombin to Improve Thromboprophylaxis and Reduce the Incidence of Trauma-Related Venous Thromboembolism (TRAIT)

The purpose of this study is to determine if additional interventions will assist with decreasing the risk and/or severity of thromboembolism (clotting complications) in patients who have experienced a major traumatic event.

Inclusion Criteria:

• Admission to trauma service
• Polytraumatic injuries OR pelvic/long bone fracture
• Planned admission to trauma ICU or step-down/SIMU setting (this includes STICU, SIMU/TIMU, BICU, and BIMU)
• Informed consent obtained

Exclusion Criteria:

• Prisoners (defined as those directly admitted from correctional facility)
• Known or suspected pregnancy
• ≥ 20% total body surface area (TBSA) burned
• Nonsurvivable head injuries
• Known hematologic or immunologic disorders
• Known prehospital anticoagulant use
• Patients initially placed on unfractionated heparin for thromboprophylaxis
• Known allergy to Antithrombin or it's components
• Enrollment in another interventional study unless approved by Trial Principal Investigator