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This study aims at evaluating the possible efficacy and safety of L-carnitine in rheumatoid arthritis via targeting Jak/STAT pathway and TGF-β1
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | No Intervention | this group will include 23 patients which will receive the traditional therapy of RA for 3 months. | |
| L-carnitine group | Active Comparator | this group will include 23 patients which will receive 500mg L-carnitine two times daily after meal plus the traditional therapy of RA for 3 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-carnitine | Drug | One 500 mg tablet twice daily after meals |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change in DAS-28-CRP score | Patients will undergo clinical assessment according to DAS-28-CRP score | 3 months |
| The change in Multidimensional Health Assessment Questionnaire (MDHAQ) score | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| The change in serum level of C-reactive protein (CRP) | Blood samples will be collected at base line and after 3 months | 3 months |
| The change in serum level of Signal transducer and activator of transcription 3(STAT 3). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Abdallah A Eldisouky | Contact | 201279142631 | PG_165476@pharm.tanta.edu.eg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta university | Recruiting | Tanta | Gharbia Governorate | Egypt |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D002331 | Carnitine |
| ID | Term |
|---|---|
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
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Blood samples will be collected at base line and after 3 months
| 3 months |
| The change in serum level of Transforming growth factor β1(TGF-β1). | Blood samples will be collected at base line and after 3 months | 3 months |
| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |