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This clinical trial aims to test in female patients with systemic lupus erythematosus (SLE). The main question it seeks to answer is whether etonogestrel implants can protect ovarian reserve function in patients with SLE. Participants will be randomly divided into a test group and a control group. The test group will be implanted subcutaneously with etongestrel for one year. Researchers won't intervene in the control group. After three months of drug-eluting, researchers will compare measures of ovarian reserve function in the test and control groups to see if etonogestrel implants can protect ovarian reserve function in patients with SLE.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Etonogestrel implants group | Experimental | Women will be subjected to etonogestrel implant (68mg) insertion. |
|
| control group | No Intervention | This group of women will not be intervened. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Etonogestrel | Drug | Etongestrel implant will be implanted subcutaneously in the participant's non-dominant arm for one year |
|
| Measure | Description | Time Frame |
|---|---|---|
| Anti-Mullerian hormone (AMH) serum level | The serum AMH levels of the two groups will be compared one year and three months after enrollment. | one year and three months |
| Measure | Description | Time Frame |
|---|---|---|
| Number of antral follicle | The number of antral follicles will be recorded by transvaginal ultrasound and compared one year and three months after enrollment. | one year and three months |
| Follicle-stimulating hormone (FSH) serum level |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiaoyan Liang | Contact | 86 020-38250752 | liangxy2@mail.sysu.edu.cn |
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| ID | Term |
|---|---|
| D008180 | Lupus Erythematosus, Systemic |
| ID | Term |
|---|---|
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| C044815 | etonogestrel |
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The serum FSH levels of the two groups will be compared one year and three months after enrollment.
| one year and three months |
| luteinizing hormone (LH) serum level | The serum LH levels of the two groups will be compared one year and three months after enrollment. | one year and three months |
| Estradiol (E2) serum level | The serum E2 levels of the two groups will be compared one year and three months after enrollment. | one year and three months |