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Post-thoracotomy pain is a challenging clinical problem that may be associated with increased morbidity and mortality. The current study tests two techniques of regional anaesthesia to control post thoracotomy pain
Post-thoracotomy pain is a challenging clinical problem that may be associated with increased morbidity and mortality.
The surgical incision produces post-thoracotomy pain (PTP) via damage to the ribs and intercostal nerves, inflammation of the chest wall, pleura or pulmonary parenchyma cutting, and placement of the intercostal chest tube. Acute PTP inhibits the ability to breathe and cough normally. Numerous analgesic techniques are used to relieve PTP, including systemic opioids, regional techniques (such as paravertebral nerve blockade, intercostal nerve blockade, intrapleural analgesia, and epidural opioids with or without local analgesia), cryo-analgesia, and transcutaneous electrical nerve stimulation (TENS).
Emerging research has shown that the novel erector spinae plane block (ESPB) can be employed as a simple and safe alternative analgesic technique for acute post-surgical, post-traumatic, and chronic neuropathic thoracic pain in adults.
ESPB was first reported in 2016 for ipsilateral thoracic analgesia. It was found to be a safe and effective block that can be performed by an emergency physician in the emergency department setting for addressing acute pain due to multiple rib fractures.
Retrolaminar block (RLB) was first reported in 2006 as an alternative approach to PVB. RLB is performed with US imaging or the landmark technique. The efficacy of continuous RLB has been reported for breast cancer surgery .
However, the efficacy of ESPB has been described in a greater number of clinical reports than has RLB: a rib fracture, breast surgery, thoracoscopic surgery, lumbar spinal surgery, and laparoscopic abdominal surgery. In contrast to RLB, most of the literature on ESPB reported the use of the single-shot technique (80.2%). The local anesthetic was postulated to infiltrate the ventral and dorsal rami of the spinal nerve. However, Ueshima et al. reported that ESPB could not provide adequate analgesia of the anterior branch of the intercostal nerve.
The rationale of the study is that to the best of our knowledge each of ESPB and RLB has limitations regarding sensory block and distribution so our hypothesis is combining both will provide more solid block regarding sensory distribution, time interval of the block efficacy, and postoperative morphine consumption in patients undergoing thoracic surgeries.
Few studies evaluated the efficacy of ultrasound (US) guided erector spinae plane block on post-thoracotomy analgesia, however for the best of our knowledge no one compared the effect of ultrasound (US) guided retrolaminar block combined with erector spinae plane block and ultrasound (US) guided erector spinae plane block alone in patients undergoing thoracic surgeries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 Erector spinae plane block | Experimental | Group 1 (ESPB (control group): (n = 15) patients will receive preoperative US-guided ESPB on the operated side by 20 ml bupivacaine 0.25%. |
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| Group 2: Erector spinae plane block | Experimental | US-guided ESPB with 10 ml bupivacaine 0.25% (n = 15) on the operated side. |
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| Retro laminar block | Experimental | the US-guided retrolaminar block 10 ml bupivacaine 0.25% group: (n = 15) on the operated side. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Erector spinae plane block | Procedure | Patients will be divided into 2 groups group 1 will receive US-guided ESPB and group 2 will receive US-guided ESPB + US-guided Retrolaminar plain block before induction of GA. |
| Measure | Description | Time Frame |
|---|---|---|
| Total amount of morphine consumption in the first 24-hour postoperative in the two groups. | 20ml for ESPB compared to 10ml ESPB added to 10ml RLB. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| •Pain score according to VAS score | Pain score according to VAS score at 30min, 2h, 4h, 8h, 12h, 24h postoperative. | 24 hours |
| • Heart rate | • Heart rate(Bpm) at 0 , 15min, 30min, 45min, 60min, 90min, 120min, then every 1h intraoperative. |
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Inclusion Criteria:
1. Inclusion criteria
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| sherif mamdouh, MD | Contact | 01141235049 | 002 | s25041989@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| sherif mamdouh, MD | Cairo University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo Unviersity | Recruiting | Cairo | Egypt |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jul 26, 2022 |
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Randomization will be accomplished through the use of computer-generated random numbers and closed opaque envelopes. Another anesthesiologist who will not be involved in the other parts of the study will open the envelopes to enroll patients. and both patients and outcome assessors will be blinded to the assignment of groups.
| erector spinae plane block + retrolaminar block | Procedure | Patients will be divided into 2 groups group 1 will receive US-guided ESPB and group 2 will receive US-guided ESPB + US-guided Retrolaminar plain block before induction of GA. |
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| intraoperative |
| Incidence of complications | •Incidence of complications as hypotension, bradycardia, postoperative nausea, vomiting (PONV) and pruritis. | 24 hours |
| .First request of analgesia postoperative | first time to request analgesia in the first 24 hrs | 24 hours |
| MAP | Mean arterial blood pressure in mmhg at 0 , 15min, 30min, 45min, 60min, 90min, 120min, then every 1h intraoperative. | intraoperative |
| Dec 16, 2022 |
| Prot_SAP_000.pdf |