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The purpose of this study was to analysis the incidence of ear symptoms, cognitive function decline and emotional disorders in Chinese people who were infected with COVID-19, exploring the impact of COVID-19 on the auditory system, cognitive function and emotional function, and analyzing the changes in functional connectivity of brain network after COVID-19 infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with hearing loss after infection | Patients with hearing loss after infection | ||
| Patients with hearing loss before infection | Patients with hearing loss before infection | ||
| Healthy control | Healthy subjects who have never been infected with COVID-19 or diagnosed with hearing loss. |
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| Measure | Description | Time Frame |
|---|---|---|
| The correlation between the peak of COVID-19 transmission and the popularity of related online terms | The correlation between the peak of COVID-19 transmission and the popularity of related online terms | through study completion, an average of 3 months |
| Symptom incidence | According to the questionnaire survey of 748 patients, the incidence of hearing loss, tinnitus, ear tightness, earache, vertigo or other cognitive and emotional problems after COVID-19 was analyzed. | through study completion, an average of 3 months |
| Pure tone average | According to the WHO grading standard of hearing loss in 1980, the average pure tone threshold (PTA) of 0.5k, 1k, 2k and 4kHz in better ears was defined as normal hearing, 26-40 dB HL(hearing level) was defined as mild hearing loss, and 41-55 dB HL was defined as moderate hearing loss. 56-70 dB HL was moderate to severe hearing loss, 71-90 dB HL was severe hearing loss, and ≥91 dB HL was extremely severe hearing loss. | through study completion, an average of 3 months |
| Mini-Mental State Examination score and grade | There are 30 points in the Mini-Mental State Examination (MMSE) scale. The score of 27-30 is normal, and 21-26 is mild dementia. 10-20 is moderate dementia; On a scale of 0 to 9, dementia is severe | through study completion, an average of 3 months |
| Montreal Cognitive Assessment score and grade | The total score of the Montreal Cognitive Assessment (MoCA) scale is 30 points, generally ≥26 points normal, 18-26 points mild cognitive impairment, 10-17 points moderate cognitive impairment, and < 10 points severe cognitive impairment. | through study completion, an average of 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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A total of 748 patients with novel coronavirus were surveyed from December 2022 to February 2023.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sun Yat-sen Memorial Hospital of Sun Yat-sen University | Guangzhou | Guangdong | 510000 | China |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D060825 | Cognitive Dysfunction |
| D004427 | Ear Diseases |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Pittsburgh Sleep Quality Interview score and grade | Pittsburgh Sleep Quality Index (PSQI) Scale total scores 21 points. A score of 0-5 indicates good sleep quality; A score of 6-10 indicates good sleep quality; 11-15 points, indicating average sleep quality; A score of 16 to 21 indicates poor sleep quality | through study completion, an average of 3 months |
| Hamilton depression score and grade | For the 24th version of Hamilton depression Scale (HAMD), the total score > 35 May indicate severe depression; 21-35, may be mild to moderate depression; 9-20, suspected depression; < 8 indicates normal. | through study completion, an average of 3 months |
| Resting state of Electroencephalogram data | Electroencephalogram (EEG) data of the study were preprocessed and trends in functional brain network connectivity were analyzed. | through study completion, an average of 3 months |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D010038 | Otorhinolaryngologic Diseases |