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The investigators currently provide the NEAR method (neuropsychological educational approach to cognitive remediation) for people with neurocognitive difficulties, without distinguishing between ASD and schizophrenia.
However, the NEAR method does not address social cognition in the stimulated functions. The aim of this study is to add social scenarios to this neurocognitive method in order to improve not only neurocognitive functions, but also social cognition. Thus, NEAR would be in this adapted form a method that could be completely adapted to autism spectrum disorders in preadolescents and adults.
The study will include participants aged 13-40 years, with a diagnosis of ASD.
The NEAR TSA method will include 32 sessions:
The method includes 30 minutes of computerized exercises, 15 minutes of discussion on the exercises performed and the strategies applied, and the rest of the time for "bridging groups".
Three evaluation are proposed:
Inclusion age:two samples: 13 to 15 years old and 16 to 40 years old the clinical evaluation (T1,T2, T3) includes: global functional assessment; questionnaires for children and adults including the self esteem questionnaire, quality of life (who_QOL Bref), social responsiveness scale, conversational skills (CCC-2 for children; Pomini Scale for adults), intrinsic motivational scale (Medalia), Satisfaction scale (CSQ8).
The Neuropsychological evaluation (T1, T2, T3) includes: WISC5 (children), WAIS 4 (adults), stroop test, D2-R, Child memory scale or Wechsler Memory scale for adults, Brief, color trail test, verbal fluency.
Near TSA is a group cognitive remediation method, including one weekly session for children or 2 weekly sessions for adults with 30 mn of neuropsychological exercices, 15 mn of discussion about exercices and strategies, and 30 mn of bridging groups including social scritps.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NEAR TSA | Experimental | Neuropsychological and Educational Approach of Cognitive Remediation, adapted for autism (NEAR-TSA) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NEAR-TSA | Other | Neuropsychological and Educational Approach of Cognitive Remediation adapted to autism 32 sessions spread over 4 to 8 months (1 session per week for minors, 2 sessions per week for adults), lasting 90 to 120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Compliance | number of sessions correctly completed/number of sessions planned | At the end of the intervention (Month 4 for adults participants, Month 8 for minor participants) |
| Enrollment rate | number of subjects recruited/number of subjects selected | at the end of the inclusion period (up to 24 months after the start of the research) |
| Retention rate | Number of subjects in post evaluation (T2)) / number of subjects recruited | At T2 (between Mont 4 and Month 5 for adults participants ; between Month 8 and Month 9 for minor participants) |
| Measure | Description | Time Frame |
|---|---|---|
| Neuropsychological assessment: attentional performance | D2-R test | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the sessions |
| Neuropsychological assessment : processing speed |
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Inclusion Criteria:
Exclusion Criteria:
Specific exclusion criteria for the "adult" group:
- heterogeneous levels of development highlighted in the diagnostic workup including an examination of cognitive functions
Specific exclusion criteria for the "children" group:
- out-of-school children
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Laura Nailler | Contact | 01.45.65.76.78 | ext.nailler@ghu-paris.fr |
| Name | Affiliation | Role |
|---|---|---|
| Isabelle Amado | GHU Paris Saint-Anne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GHU Paris Saint-Anne | Recruiting | Paris | France |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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D2 test |
| before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the sessions |
| Neuropsychological assessment : flexibility (1) | Color Trail Test (raw score) | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the session |
| Neuropsychological assessment : flexibility (2) | verbal fluency test (raw score and z-score) | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the session |
| Neuropsychological assessment : flexibility (3) | Stroop test (raw score and z-score) | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the session |
| Neuropsychological assessment : working memory | Child memory scale for minor <16 years, Wechsler's memory scale for other participants | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the sessions |
| Functional assessment: quality of life | World Health Organization Quality of Life-BREF (WHO QOL-BREF) (26 items rated on a 5-level scale (score from 1 to 5)) | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the sessions |
| Functional assessment : conversational skills | CCC-2 (Children's Communication Check list) for minors <16 years (Raw Score, Scaled Score, Percentile) | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the sessions |
| Functional assessment : conversational skills (2) | Pomini's Conversational Skills Scale (1999) for other participants (16 items, score from 0 to 3 for each ; maximum total score : 48) | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the sessions |
| Functional assessment: self-esteem | Rosenberg's Self-Esteem Scale (10 items, score from 1 to 4 for each - total score between 10 and 40) | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the sessions |
| Functional assessment: global functioning | Global assessment of functioning scale (total score between 0 and 100) | before the start of the NEAR TSA sessions, within one month of the end of the sessions and 3 to 4 months after the end of the sessions |