Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this observational study is to evaluate and to correlate melatonin levels in plasma, saliva and cerebrospinal fluid (CSF) samples of patients undergoing lumbar puncture diagnostic for specific neurological diseases.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AD | Alzheimer's Disease |
| |
| NON AD | Non Alzheimer's Disease |
| |
| CT | Controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood and saliva sample and lumbar puncture diagnostic for specific neurological diseases | Other | Saliva was collected using Salivettes (Sarsted, Newton, NC, USA) in dim light. CSF was obtained in the morning after overnight fasting by lumbar puncture at the L3/L4 or L4/L5 interspace. Blood samples were drawn in fasting conditions. Plasma was separated by centrifugation. |
| Measure | Description | Time Frame |
|---|---|---|
| Melatonin levels in saliva | Analysis of melatonin levels by ELISA kit. Values expressed in pg/ml | Baseline |
| Melatonin levels in plasma | Analysis of melatonin levels by ELISA kit. Values expressed in pg/ml | Baseline |
| Melatonin levels in cerebrospinal fluid | Analysis of melatonin levels by ELISA kit. Values expressed in pg/ml | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Orexin levels in cerebrospinal fluid | Analysis of orexin levels by ELISA kit. Values expressed in ng/ml | Baseline |
| Neurofilaments light chain levels (NFL) in cerebrospinal fluid | Analysis of NFL levels by SIMOA kit. Values expressed in pg/ml |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Neurodegenerative disorders
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Stefania Cattaldo | Contact | 0323514345 | s.cattaldo@auxologico.it |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istituto Auxologico Italiano - S. Giuseppe Hospital | Recruiting | Verbania | VB | Italy |
Not provided
| ID | Term |
|---|---|
| D019636 | Neurodegenerative Diseases |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D013129 | Spinal Puncture |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
Not provided
Not provided
Not provided
Not provided
Not provided
Plasma, saliva and cerebrospinal fluid
|
| Baseline |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D001706 | Biopsy |
| D003943 | Diagnostic Techniques, Neurological |
| D013812 | Therapeutics |