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The prevalence of ascariasis in COPD patients with and without concomitant pulmonary aspergillosis and in controls will be determined. To assess the influence of ascaridosis on the development of pulmonary aspergillosis in COPD patients cytokine status of patients will be studied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COPD patients without any comorbidities | Active Comparator |
| |
| COPD patients with chronic pulmonary aspergillosis | Active Comparator |
| |
| COPD patients with ascariasis | Active Comparator |
| |
| COPD patients with chronic pulmonary aspergillosis and ascariasis | Active Comparator |
| |
| healthy control | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Interleukin-1B | Diagnostic Test | Level of serum interleukin-1B will be detected |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum interleukin-1B levels in COPD patients and controls | Serum interleukin-1B (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. | up to 12 months |
| Serum interleukin-4 levels in COPD patients and controls | Serum interleukin-4 (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. | up to 12 months |
| Serum interleukin-6 levels in COPD patients and controls | Serum interleukin-6 (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. | up to 12 months |
| Serum tumor necrosis factor-a levels in COPD patients and controls | Serum tumor necrosis factor-a (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. | up to 12 months |
| Serum interferon-gamma levels in COPD patients and controls | Serum interferon-gamma (pg/mL) levels will be measured in COPD patients without concomitant infection, COPD patients with pulmonary aspergillosis, COPD patients with ascariasis, COPD patients with ascariasis and pulmonary aspergillosis, and healthy individuals. |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of ascariasis infestation among COPD patients and controls | The frequency of ascariasis infestation among COPD patients with and without pulmonary aspergillosis, as well as healthy individuals, will be assessed. | up to 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Abdurakhim Dr Toychiev, PhD | Contact | +998901358977 | abdurahim1988@gmail.com | |
| Svetlana Dr Osipova, PhD | Contact | +998712774008 | svetosip7@mail.ru |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research institute of epidemiology, microbiology and infectious diseases | Recruiting | Tashkent | Uchtepa | 100133 | Uzbekistan |
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| Interleukin-4 | Diagnostic Test | Level of serum interleukin-4 will be detected |
|
| Interleukin-6 | Diagnostic Test | Level of serum interleukin-4 will be detected |
|
| tumor necrosis factor - a | Diagnostic Test | Level of serum tumor necrosis factor - a will be detected |
|
| interferon- gamma | Diagnostic Test | Level of serum interferon- gamma will be detected |
|
| up to 12 months |
| Correlation between cytokine status with chronic pulmonary aspergilosis insidence rate in COPD patients with and without ascariasis | The correlation between serum interleukin-1B, interleukin-4, interleukin-6, tumor necrosis factor-a and interferon-y levels with chronic pulmonary aspergilosis insidence rate in COPD patients with and without ascariasis will be assessed. | up to 12 months |
| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D001228 | Aspergillosis |
| D001196 | Ascariasis |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009181 | Mycoses |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D017191 | Ascaridida Infections |
| D017190 | Secernentea Infections |
| D009349 | Nematode Infections |
| D006373 | Helminthiasis |
| D010272 | Parasitic Diseases |
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| ID | Term |
|---|---|
| D059425 | Interferon-gamma Release Tests |
| ID | Term |
|---|---|
| D007159 | Immunologic Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D007158 | Immunologic Techniques |
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