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Patient undergoing surgery is exposed to many stressors: diachronic (gesture anticipation), synchronic (intraoperative aggression) and historical (subject's personality). Reducing the level of stress experienced is a factor for improving the quality of the surgical gesture and the simplicity of the follow-up. The previous methods used were intended to reduce the body's reactivity to aggressions through anaesthesia consultation and L-Tyrosine supplementation. Currently with the progression of outpatient surgery and the need for early rehabilitation, L-Tyrosine supplementation is suppressed to improve recovery. Some patients, however, have a high level of stress that may require anxiolysis when the ideal treatment does not exist (ineffective hydroxyzine, benzodiazepines having many side effects). The strategy of this work is to improve the body's ability to respond to stressors, by administering l-tyrosine with no impact on waking or returning home.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| L-Tyrosine | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-tyrosine supplementation | Dietary Supplement | L-Tyrosine supplementation before surgery for inguinal hernia under general anaesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Variation of anxiety status | Anxiety score measured using Y-A STAI | between the day before surgery and thes day after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Other stress markers variation | anxiety visual analogue scale (from 0 to 10, 10 is worst) | the day before surgery |
| Other stress markers variation | anxiety visual analogue scale (from 0 to 10, 10 is worst) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bertrand PRUNET, PU-PH | Contact | +377 97 98 98 19 | bertrand.prunet@chpg.mc | |
| Nicolas RIJO | Contact | +377 97 98 84 45 | nicolas.rijo@chpg.mc |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHPG | Recruiting | Monaco | 98000 | Monaco |
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prospective, monocentric, double-blind randomized study
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| Placebo supplementation | Dietary Supplement | Placebo supplementation before surgery for inguinal hernia under general anaesthesia |
|
| the day after surgery |
| Other stress markers variation | heart blood pressure (Systolic and diastolic) | the day before surgery |
| Other stress markers variation | heart blood pressure (Systolic and diastolic) | the day after surgery |
| Other stress markers variation | cortisol dosage | the day before surgery |
| Other stress markers variation | cortisol dosage | the day after surgery |