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Bone metabolism and genetic characteristics of osteoporosis pedigree with kidney-yang deficiency
Families with or without osteoporosis of kidney-yang deficiency type will be included and compared with each other. Their genetic characteristics, bone changes, and TCM constitution are the focus of research.
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| Measure | Description | Time Frame |
|---|---|---|
| changes in bone mineral density from baseline to 5 years after enrollment | lumbar (L1-4 as well as total) and hip bone mineral density will be recorded by dual energy X-ray absorptiometry | at enrollment |
| changes in bone mineral density from baseline to 5 years after enrollment | lumbar (L1-4 as well as total) and hip bone mineral density will be recorded by dual energy X-ray absorptiometry | 5 years after enrollment |
| Physical phenotype of traditional Chinese medicine | Occurrence of kidney yang deficiency | at enrollment |
| Physical phenotype of traditional Chinese medicine | Occurrence of kidney yang deficiency | 5 years after enrollment |
| Understand the general situation through the questionnaire | Including age（year）, sex（man,wowan）, height(cm), weight(kg), menstrual period,history of smoking and drinking, living habits, fracture history and risk assessment, skeletal muscle assessment, living environment, Chinese medicine constitution, etc | at enrollment |
| Understand the general situation through the questionnaire | Including age（year）, sex（man,wowan）, height(cm), weight(kg), menstrual period,history of smoking and drinking, living habits, fracture history and risk assessment, skeletal muscle assessment, living environment, Chinese medicine constitution, etc | 5 years after enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| Osteocalcin | serum osteocalcin | at enrollment |
| procollagen type I N-terminal propeptide | serum procollagen type I N-terminal propeptide (PINP) |
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Inclusion Criteria:
Exclusion Criteria:
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member of family
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yongjun Wang | Contact | 86-21-64385700 | 9903 | yjwang88@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Yongjun Wang | Shanhgai University of TCM | Study Chair |
| Chuanglong Xu | Ningxia Chinese medicine Rearch Center | Study Director |
| Zhangyu Liao |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nankang Traditional Chinese Medicine Hospital | Recruiting | Gannan | Jiangxi | 341000 | China |
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Serum, saliva
| at enrollment |
| Bone alkaline phosphatase | serum bone alkaline phosphatase (BALP) | at enrollment |
| β-crosslaps | serum β-crosslaps (β-CTX) | at enrollment |
| Ca | serum Ca | at enrollment |
| P | serum P | at enrollment |
| Mg | serum Mg | at enrollment |
| Fibroblast growth factor | serum fibroblast growth factor (FGF)23 | at enrollment |
| Parathormone | serum parathormone (PTH) | at enrollment |
| 25(OH) vitamin D | serum total 25(OH) vitamin D | at enrollment |
| Osteocalcin | serum osteocalcin | 5 years after enrollment |
| Procollagen type I N-terminal propeptide | serum procollagen type I N-terminal propeptide (PINP) | 5 years after enrollment |
| Bone alkaline phosphatase | serum bone alkaline phosphatase (BALP) | 5 years after enrollment |
| β-crosslaps | serum β-crosslaps (β-CTX) | 5 years after enrollment |
| Ca | serum Ca | 5 years after enrollment |
| P | serum P | 5 years after enrollment |
| Mg | serum Mg | 5 years after enrollment |
| Fibroblast growth factor | serum fibroblast growth factor (FGF)23 | 5 years after enrollment |
| Parathormone | serum parathormone (PTH) | 5 years after enrollment |
| 25(OH) vitamin D | serum total 25(OH) vitamin D | 5 years after enrollment |
| Gene testing(BGIseq T5,WGS) | Carry out whole-gene testing on the samples with obvious family heritability of osteoporosis, and analyze the differences at the gene level through sequencing compared with the control group | at enrollment |
| Gene testing(BGIseq T5,WGS) | Carry out whole-gene testing on the samples with obvious family heritability of osteoporosis, and analyze the differences at the gene level through sequencing compared with the control group | 5 years after enrollment |
| Nankang Traditional Chinese Medicine Hospital |
| Study Director |
| Ningxia Chinese medicine Rearch Center | Recruiting | Yinchuan | Ningxia | 750000 | China |
|
| Longhua Hospital, Shanghai University of TCM | Recruiting | Shanghai | China |
|