Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study aims to find an easy urinary collection method for the assessment of urinary markers of micronutrient status.
Urinary collection in newborns and infants can be difficult. Our study aims to find an easy and cheap alternative to urinary collection bags and specialized pads that can be used to measure biomarkers of iodine and vitamin B12 status in urine and can be employed in large scale trials. Using correlation analyses, the association of urinary iodine and methylmalonic acid from healthy volunteers will be assessed between untreated sample and a sample expressed from a sanitary napkin. Participants will be recruited based on their dietary pattern (omnivorous, vegetarian and vegans) to have a broad spectrum of analyte concentration. Participants weight, height, age, nutritional supplement use and diet will be assessed.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Omivorous | Healthy volunteers without dietary restrictions |
| |
| Vegetarians | Healthy volunteers who do not consume meat products |
| |
| Vegans | Healthy volunteers who do not consume any animal product |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Urine collection and assessment of dietary intake by food frequency questionaire | Diagnostic Test | urinary iodine, creatinine and methylmalonic acid, iodine and vitamin B12 dietary intake from foods and supplements |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation untreated and expressed urine | Correlation of creatinine, methylmalonic acid and iodine between unprocessed urine and urine expressed from a sanitary diaper to evaluate possible matrix effects on analytes. | 8-9 weeks after completion |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of urinary biomarkers with food and supplement intake | Correlation of dietary intake assessed by a food frequency questionnaire with urinary iodine and methylmalonic acid normalized to creatinine. | 8-9 weeks after completion |
| Measure | Description | Time Frame |
|---|---|---|
| Mean difference of urinary biomarkers between groups | Exploratory analysis of differences by dietary group in urinary iodine nomalized to creatinin. | 8-9 weeks after completion |
| Mean difference of urinary biomarkers between groups |
Inclusion Criteria:
Healthy volunteers Written informed consent
Exclusion Criteria:
BMI < 18,5 and >24,9 Use of medication (except contraceptives) Smoking
Not provided
Not provided
Participants are primarily recruited at the University of Hohenheim
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Hohenheim | Stuttgart | Baden-Wurttemberg | 70599 | Germany |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D059349 | Urine Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
Not provided
Not provided
Not provided
Not provided
Not provided
Exploratory analysis of differences by dietary group in methylmalonic acid nomalized to creatinin.
| 8-9 weeks after completion |
| D008919 | Investigative Techniques |