To goal of this clinical trial is to quantify the dose-response effects of aerobic exercise training compared to attention control on chemotherapy relative dose intensity in colon cancer survivors.

Inclusion Criteria:

• Age ≥18 years
• Histologically confirmed stage II or III colon cancer
• Completed surgical resection with curative intent
• Plan to initiate chemotherapy
• Engage in <60 minutes per week of moderate- to vigorous-intensity structured aerobic exercise
• No planned major surgery during the study period
• Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
• Can walk 400 meters
• Can read and speak English
• Ability to provide written informed consent
• Provide written approval by qualified healthcare professional
• Willing to be randomized

Exclusion Criteria:

• Evidence of metastatic colon cancer
• Concurrently actively treated other (non-colon) cancer
• Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
• Currently participating in another study with competing outcomes
• Any other condition that, in the opinion of the investigator, would preclude participation or successful compliance with the protocol
• Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol