This study aims to examine the effectiveness of a supervised aerobic exercise program for persons with Opioid Use Disorder (OUD). Participants will be enrolled in a 12-week supervised aerobic exercise intervention.

The overall project goals are to test the feasibility and acceptability of our aerobic exercise intervention with this population. Study participation will include a screening and enrollment phase, a baseline assessment, and a 12-week intervention. Participants will be recruited and consented by University of Florida (UF) study staff.

Inclusion Criteria:

• Adults must be aged 21-64 years old
• Currently enrolled in OMT (opioid maintenance treatment) or present with at least mild opioid use disorder (endorses at least 2 DSM-V criteria for OUD within a 12-month period),
• Insufficiently physically active (defined as exercising < 20 minutes 3 times/week
• Able to understand and speak English
• Have a body mass index 18.5-40 kg/m^2
• Willing and able to visit research center up to one time time/week for 12 weeks
• Participants will undergo a supervised maximal exercise test and physical exam by medical supervisor to be cleared for participation.

Exclusion Criteria:

• Participants must not have heart disease, or had a stroke, uncontrolled diabetes, thyroid condition an eating disorder
• An uncontrolled major psychiatric condition (e.g., schizophrenia; conditions that are well-controlled, however [e.g., anxiety controlled through therapy] will not be exclusionary), or other medical condition(s) that contraindicate exercise; and may not be participating in a structured exercise training or weight loss program.
• Participants cannot be pregnant; pregnancy is exclusionary
• One individual per household may enroll.