Additional Effects of Vagus Nerve Stimulation on Motor Functions of Upper-limb in Stroke

Additional Effects of Vagus Nerve Stimulation With Task-oriented Training on Motor Functions of Upper-limb in Stroke

The study aims to determine the additional effects of vagus nerve stimulation with task-oriented training on motor functions of upper-limb in stroke

Stroke is a clinical syndrome characterized by rapidly developing clinical signs of focal (or global) disturbance of cerebral function lasting more than 24 hours or leading to death with no apparent cause. Nerve stimulation paired with rehabilitation is a novel potential treatment option for people with long-term moderate-to-severe arm impairment after stroke. The study aims to determine the additional effects of vagus nerve stimulation with task-oriented training on motor functions of upper-limb in stroke. The idea of stimulating the vagus nerve to modify central brain activity has been pursued. Vagus nerve stimulation (VNS) paired with rehabilitative training enhances recovery of function in models of stroke and is currently under investigation for use in chronic stroke patients. Compared to traditional stimulation, noninvasive VNS seems to be safer and more tolerable.

Inclusion Criteria:

• Sub-Acute stroke (3 months to 6 months)
• Between grade 0 and grade 2 on modified Ashworth scale.
• Patients who will be able to walk without assisted devices and can stand for 2 minutes.
• Either type Ischemic or Hemorrhagic
• Age bracket 40-60 Years

Exclusion Criteria:

• Previous surgical intervention on vagus nerve
• Severe pain in upper extremity
• MoCA score of less than 10