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Brachial plexus block is used for upper limb surgery. Local anesthesia alone for brachial plexus block provides good operative conditions, but have short duration of postoperative analgesia. Hence, various adjuvants to local anaesthetic agents to prolong the duration of peripheral nerve, analgesia. However, results are either inconclusive or associated with side effects. The purpose of this study is to determine whether dexmedetomidine as an adjuvant to ropivacaine in brachial plexus block improve quality of block in terms of duration of post operative analgesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group R | Active Comparator | 0.35% ropivacaine 20ml, 1.5% lidocaine with adrenaline 10ml = 30 ml |
|
| Group RD | Experimental | 0.35% ropivacaine and 1mcg/ kg dexmedetomidine (20 ml), 1.5% lidocaine with adrenaline (10ml) = 30 ml |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ropivacaine, lidocaine with adrenaline | Drug | Group R includes 0.35% ropivacaine 20ml, 1.5 % lidocaine with adrenaline 10ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assess the duration of analgesia after brachial plexus block with ropivacaine and dexmedetomidine | Analgesia will be assessed with the help of Visual analogue score ( VAS). VAS greater than 3 will be given inj.ketorolac 30mg IV. | 5 months |
| Assess the onset of sensory and motor block after brachial plexus block with ropivacaine and dexmedetomidine | Sensory block assessed by 3point scale 0 normal sensation
0-able to raise extended arm to 90 degree for full two seconds
| 5 months |
| Assess the duration of sensory and motor block after brachial plexus block with ropivacaine and dexmedetomidine | Duration of sensory block, defined as time interval between complete sensory block and complete resolution of anesthesia (score 0). Duration of motor block defined as time interval from complete motor block to recovery of complete motor function (MBS 0). | 5months |
| Measure | Description | Time Frame |
|---|---|---|
| Assess any complications of study drugs | Complications like bradycardia assessed by continue ECG monitoring, Hypotension will be assessed by NIBP | 5 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nepal medical college | Kathmandu | Bagmati | 0096 | Nepal |
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| Dexmedetomidine, ropivacaine, lidocaine with adrenaline | Drug | Dexmedetomidine 1mcg/kg and 0.35% ropivacaine with normal saline (20ml), 1.5% lidocaine with adrenaline (10ml) in group RD |
|
| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| D008012 | Lidocaine |
| D004837 | Epinephrine |
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D000083 | Acetanilides |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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