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| Name | Class |
|---|---|
| Radboud University Medical Center | OTHER |
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This case-control study aims to investigate if oral microbioma is associated with developing oral (pre)malignant disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with no oral malignant disease | |||
| Patients with oral premalignant disease | |||
| Patients with oral malignant disease |
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| Measure | Description | Time Frame |
|---|---|---|
| Association between oral microbioma and (pre)malignant disease. | Prevalence of clusters of different oral pathogens will be displayed for patients with malignant disease, premalignant disease and no oral malignancy. Taxonomic representation of statistically and biologically consistent differences between patients with malignant disease, premalignant disease and no oral malignant disease will be displayed. | Through study completion, an average of 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| To describe the difference in oral microbioma between young (>40 years) patients with oral SCC and older (>40 years) patients with oral squamous cell carcinoma. | Prevalence of different oral pathogens will be displayed for patients of both age groups. | Through study completion, an average of 3 years |
| To desribe the difference in oral microbioma and stage of disease upon presentation. |
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Inclusion Criteria:
Exclusion Criteria:
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Persons visiting oral and maxillofacial surgery department in Maastricht UMC or Radboud UMC who meet the inclusion criteria can be included.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| L.A.A. Vaassen | Contact | +31 (0)43 3872010 | lauretta.vaassen@mumc.nl | |
| E.R.C. Hagens | Contact | +31 (0)43 3872479 | eliza.hagens@mumc.nl |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Deptartment of Oral and Maxillofacial Surgery, Maastricht UMC+ | Recruiting | Maastricht | Netherlands | |||
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| ID | Term |
|---|---|
| D009062 | Mouth Neoplasms |
| D000077195 | Squamous Cell Carcinoma of Head and Neck |
| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D009059 | Mouth Diseases |
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Prevalence of different oral pathogens will be displayed for patientgroups with different tumor stages. |
| Through study completion, an average of 3 years |
| Department of Cranio- & Maxillofacial surgery, Radboud UMC |
| Recruiting |
| Nijmegen |
| Netherlands |
| D009057 |
| Stomatognathic Diseases |
| D002294 | Carcinoma, Squamous Cell |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |