Mechanisms of Type 1 Diabetes Endophenotypes

Mechanisms of Type 1 Diabetes Endophenotypes, by Cluster Analysis

The goal of this observational study consists of performing cluster analysis to decipher underlying disease mechanisms of type 1 diabetes in children and young adults.

To this end, we will combine clinical, laboratory, genetic, transcriptomic, and metabolomic datasets of an extensively phenotyped cohort of children and young adults with type 1 diabetes. We will also assess the risk for cardiovascular diseases in this most vulnerable diabetes cohort.

Inclusion Criteria (Type 1 Diabetic patients):

• Informed consent as documented by signature
• Patient's age: between 0 and 25 years old.
• Children, adolescents, and young adult patients followed in diabetology.

Exclusion Criteria (Type 1 Diabetic patients):

• No exclusion criteria

Inclusion Criteria (Controls):

• Informed consent as documented by signature
• Patient's age: 25 less than 6 years of age and 25 between 6 and 25 years old.
• Healthy patient

Exclusion Criteria (Controls):

• Patient receiving treatment affecting metabolic control (ex: systemic corticoids, beta blocker, immunotherapy etc.)
• Concomitant disease that may affect the analysis of the results (ex: cancer, active autoimmune disease requiring treatment)