Hypothesis: Type 2 diabetes mellitus is associated with pancreatic fibrosis that can be evaluated by minimally invasive imaging techniques. That fibrosis is associated with alteration of exocrine pancreatic function, defined as a reduced secretion of pancreatic enzymes and the development of nutritional deficiencies.

To test that hypothesis, a prospective, observational, cross-sectional, comparative, case-control study has been designed.

Pancreatic fibrosis will be evaluated by endoscopic ultrasound and quantitative elastography in cases (type-2 diabetes) and age-gender-matched controls without diabetes.

Pancreatic function will be explored by fecal elastase test and nutritional evaluation.

Calculated sample size is 94 patients (47 cases and 47 controls). Study period is 2 years.

Inclusion Criteria:

• Patients older than 18 years.
• Undergoing an upper endoscopic ultrasound for any indication other than pancreatic disease.
• Signed informed consent-
• Patients: Previous diagnosis of type-2 diabetes mellitus.
• Controls: Nondiabetic subjects, matched by age, gender, alcohol consumption, and smoking with patients.

Exclusion Criteria:

• History of pancreatic disease or surgery.
• History of upper gastrointestinal surgery.
• Diabetes type other than type-2.
• Severe cardiovascular or respiratory disease.
• Lack of informed consent.

Adult diabetic (patients) and nondiabetic (controls) undergoing endoscopic ultrasound for indications other than evaluation of the pancreas due to suspected or known pancreatic disease.