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| Name | Class |
|---|---|
| Instituto de Salud Carlos III | OTHER_GOV |
| Sociedad Española de Neumología y Cirugía Torácica | OTHER |
| Sociedad Valenciana de Neumología | UNKNOWN |
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International and national clinical guidelines recommend short antibiotic regimens in patients with non-severe community-acquired pneumonia (CAP) who have reached clinical stability. However, adherence to these recommendations remains unclear. The goals of this quasi-experimental trial are: 1) to assess adherence to clinical guidelines in relation to the duration of antibiotic treatment in patients hospitalized for non-severe CAP who have reached clinical stability; 2) increase adherence to clinical guidelines and reduce the use of antibiotics in patients hospitalized for non-severe CAP who have achieved clinical stability after at least 5 days of antibiotic treatment.
To this end, a multicenter prospective study will be carried out over 2 years and divided into 2 phases: i) during the first year (observational phase), patients with CAP hospitalized in the participating centers will be recorded to assess objective 1; ii) to achieve objective 2, at the beginning of the second year (quasi-experimental trial) the centers will be randomized into 2 groups of hospitals, one of them a control group and the other an intervention group. The intervention will consist in automatic reminders through pop-up windows in the computerized prescription software, reminding the clinician responsible for each patient of the need to adhere to clinical guidelines regarding the duration of antibiotic treatment in patients with clinical stability.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard of care | No Intervention | Patients allocated in hospitals randomized to non-interventional arm. Observational analysis of patients treated by clinicians with standard of care. | |
| Interventional | Other | Patients allocated in hospitals randomized to interventional arm. Intervention: automatic reminders through pop-up windows in the computerized prescription software, reminding the clinician responsible for each patient of the need to adhere to clinical guidelines regarding the duration of antibiotic treatment in patients with clinical stability |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Reminders to the assistant clinicians of the need to adhere to clinical guidelines regarding the duration of antibiotic treatment community-acquired pneumonia | Behavioral | Automatic reminders through pop-up windows in the computerized prescription software, reminding the clinician responsible for each patient of the need to adhere to clinical guidelines regarding the duration of antibiotic treatment in patients with clinical stability |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of antibiotic treatment | Total duration in days of antibiotic treatment (including the days of outpatient antibiotic prescribed at discharge). | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of antibiotic treatment after reaching clinical stability | Duration in days of antibiotic treatment after reaching clinical stability | 90 days |
| Patients treated with an adequate duration of 5±1 days |
| Measure | Description | Time Frame |
|---|---|---|
| Factors related to excess of antibiotic treatment | Factors o variables related to excess of antibiotic treatment | 90 days |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Raúl Méndez, MD, PhD | Contact | +34 961244000 | 485629 | rmendezalcoy@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Raúl Méndez, MD, PhD | Instituto de Investigación Sanitaria La Fe | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University and Polytechnic Hospital La Fe | Recruiting | Valencia | Spain |
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|
Percentage of patients treated with an adequate duration of 5±1 days
| 90 days |
| Patients admitted to the ICU after the 5th day | Percentage of patients admitted to the ICU after the 5th day of admission | 90 days |
| Mortality | Percentage of patients who died during the study | 90 days |
| Readmission | Percentage of patients who are readmitted after hospital discharge | 90 days |
| Reintroduction of antibiotic treatment | Percentage of patients with reintroduction of antibiotic treatment | 90 days |
| Length of hospital stay | Length of hospital stay in days | 90 days |
| Adverse events related to antibiotic treatment | Percentage of patients with adverse events related to antibiotic treatment | 90 days |
| ID | Term |
|---|---|
| D000098968 | Community-Acquired Pneumonia |
| D011014 | Pneumonia |
| ID | Term |
|---|---|
| D017714 | Community-Acquired Infections |
| D007239 | Infections |
| D012141 | Respiratory Tract Infections |
| D012140 | Respiratory Tract Diseases |
| D008171 | Lung Diseases |
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