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| Name | Class |
|---|---|
| National Science and Technology Council, Taiwan | OTHER_GOV |
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The goal of this observational study is to develop a computation model for accurately predicting post-induction hypotension in patients receiving laparoscopic surgery under general anesthesia. The main question[s] it aims to answer are:
• whether the corresponding characteristics on pressure wave forms could be use to predict post-induction hypotension.
Participants will be observed before and after induction of general anesthesia for non-invasive arterial pressure wave forms and blood pressure changes.
In this project, an equivalent circuit model will firstly be established to simulate patient's hemodynamics. This model will be applied into analyzing blood pressure wave forms in the MIMIC II database. It will facilitate deep understanding of the effects of induction drugs on pressure waveforms. As a result, the corresponding characteristics on pressure wave forms will be identified. The extracted characteristics from the MIMIC II database will then be applied for developing a computation model via machining learning approaches. The developed model will be validated with another available dataset of 100 patients. This project will then conduct a non-invasive and observational clinical study of 50 patients to prove the clinical value of this project. In this trial, a novel pressure sensor will be employed on patient's fingertip to continuously collect pressure waveform before and after anesthesia induction. Medical records and vital signs will also be collected for exploring the potential of the developed model for predicting other events. Endoscopic surgery patients will be recruited in this study.
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| Measure | Description | Time Frame |
|---|---|---|
| waveform characteristics predicting post-induction hypotension | An equivalent circuit model will firstly be established to simulate patient's hemodynamics. This model will be applied into analyzing blood pressure waveforms in the MIMIC II database. | Evaluated during the induction period of general anesthesia. |
| Measure | Description | Time Frame |
|---|---|---|
| effects of induction effects of induction drugs on vessels | Evaluate the specific effects of anesthetics on characteristics of pressure waveform. | off-line analysis |
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Inclusion Criteria:
Exclusion Criteria:
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Patients receiving laparoscopic surgeries under general anesthesia.
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| Name | Affiliation | Role |
|---|---|---|
| Chuen-Chau Chang, MD, PhD | Taipei Medical University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesia, Taipei Medical University Hospital | Taipei | 110 | Taiwan |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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