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The goal of this observational study is to compare cerebral perfusion patterns with pseudo-continuous arterial spin labeling (pCASL) and brain metabolism patterns with fluorodeoxyglucose-position emission tomography (FDG-PET) in patients with mild cognitive impairment (MCI) and subjective cognitive decline (SCD). The main questions it aims to answer are:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| pCASL | Diagnostic Test | Brain 3 Tesla MRI with pCASL sequence |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between brain hypoperfusion and brain hypometabolism at baseline | The investigators will correlate cerebral perfusion indices and standardized uptake value ratios (SUVr) ratios for each pre-specified region of interest (ROI) within statistical parametric mapping (SPM) Automatic Anatomic Labeling (AAL), after coregistration on T1 sequences | Baseline |
| Correlation between brain hypoperfusion and brain hypometabolism at baseline according to CSF profile | The investigators will correlate cerebral perfusion indices and SUVr for each pre-specified ROI (region of interest) within SPM Automatic Anatomic Labeling (AAL), after coregistration on T1 sequences. This analysis will be done within subgroups according to CSF status according to amyloid beta, phosphorylated tau and total tau. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Differences among brain hypoperfusion patterns according to amyloid and tau status | The investigators will analyze differences in brain perfusion indices for each ROI among patients wit amyloid positive status, amyloid and tau negative status, and amyloid negative - tau positive status | Baseline |
| Correlations between brain hypoperfusion and neuropsychological tests |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with mild cognitive impairment
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondazione IRCCS San Gerardo dei Tintori | Monza | MB | 20900 | Italy |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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Blood and CSF samples
The investigators will perform correlations between brain hypoperfusion indices for each ROI and various neuropsychological (NPS) test scores |
| Baseline, 1 year, 2 years |
| Predictive properties of brain hypoperfusion and brain hypometabolism for conversion to dementia | The investigators will analyze correlations between each ROI hypoperfusion and conversion to dementia rates within the prespecified time frame. In case of significant associations, a receiver operating characteristic curve (ROC) analysis will be carried out to individuate optimal cut-offs for cerebral blood flow indices and SUVr to predict conversion of dementia | 1 year, 2 years |
| Correlations between brain hypoperfusion and CSF and blood biomarkers | The investigators will perform correlations between brain hypoperfusion indices for each ROI and values of CSF and blood amyloid beta, phosphorylated tau and total tau | Baseline |