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| Name | Class |
|---|---|
| University of Thessaly | OTHER |
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the study compares two non-invasive respiratory support modalities ie CPAP and High Flow nasal cannula oxygen for the treatment of severe hypoxemic respiratory failure attributed to Community acquired Pneumonia.
CPAP and High Flow nasal cannula oxygen are two established modalities for non-invasive respiratory support . In COVID pandemic era both CPAP and HFNO were widely used in the ward for the treatment of COVID-19 induced acute hypoxemic respiratory failure in order to prevent progression to intubation. Head to head comparison between the two modalities mentioned for the treatment of severe hypoxemic respiratory failure is not available neither in COVID pneumonia or Community acquired pneumonia (CAP).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CPAP | When a patient needs FiO2 >50% to keep SpO2 >93%, or SpO2 >95% in case of persistent respiratory distress defined as RR>35/min, full face CPAP will be applied |
| |
| HFNO | When a patient needs FiO2 >50% to keep SpO2 >93%, or SpO2 >95% in case of persistent respiratory distress defined as RR>35/min, HFNO will be applied |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CPAP | Device | CPAP will be delivered with a CPAP valve with venturi flow system with full-face mask. Treatment will start with CPAP set at 10cmH2O and FiO2 60% to target a SpO2 ≥90% or PO2 ≥60mmHg and then adjusted according to SpO2, respiratory distress and clinical tolerance |
| Measure | Description | Time Frame |
|---|---|---|
| days free from ventilatory support | days without support with either mechanical ventilation, HFNO, CPAP | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| treatment failure defined | no of patients that needed intubation and invasive mechanical ventilation or died | 28 days |
| intubation rate | 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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Adult Patients with community acquired pneumonia induced acute hypoxemic respiratory failure that are hospitalized in the common ward and need FiO2 >50% to keep SpO2 >93%, or SpO2 >95% in case of persistent respiratory distress defined as RR>35/min.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| IOANNA SIGALA, PhD | Contact | +302132041712 | giannasig@yahoo.com | |
| IOANNIS KALOMENIDIS, PhD | Contact | +302132041712 | ikalom@med.uoa.gr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Evaggelismos Hospital | Recruiting | Athens | Attica | 10676 | Greece |
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| ID | Term |
|---|---|
| D011014 | Pneumonia |
| D012131 | Respiratory Insufficiency |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| HFNO | Device | HFNO will be applied initially at maximal settings: 100% FiO2, flow rate 60 L/min and temperature 37C . Within 1 to 2 h, the HFNO settings should be titrated based on patients respiratory rate (<25-30 per minute), SpO2 (92-96%) and comfort |
|
| hospital mortality | 28 days |
| days under non-invasive respiratory support | days without support with HFNO or CPAP | 28 days |
| hospital length of stay | 28 days |
| Partial pressure of oxygen PaO2 change at 2h, 12h and 24h | 28 days |
| University General Hospital of Larissa | Recruiting | Larissa | Thesaly | 41110 | Greece |
|
| D012120 |
| Respiration Disorders |