This prospective study was conducted in a tertiary university hospital. The investigators researched the correlation between MRE-assessed stiffness of the liver and spleen and the Hepatic venous pressure gradient (HVPG) values. Furthermore, the investigator evaluated whether MRE-assessed stiffness reflected changes in portal hypertension (PH) after administering non-selective beta-blockers (NSBBs).

Inclusion Criteria:

• diagnosed liver cirrhosis
• requiring prophylactic treatment of esophageal varices

Exclusion Criteria:

• the coexistence of hepatocellular carcinoma
• refractory ascites who regularly underwent large-volume paracentesis
• the use of selective beta-blocker or carvedilol therapy for at least 4 weeks
• undergoing liver transplantation
• contraindication with magnetic resonance imaging

Patients requiring prophylactic treatment of esophageal varices