Clinico-immunological Characterization and Immune Tolerance Breakdown in HU-autoimmunity

Clinico-immunological Characterization and Immune Tolerance Breakdown in HU-autoimmunity

Phenotypic characterization of patients with Hu-Abs, including the different neurological presentation and the presence or not of an underlying cancer.

Analysis and clinical correlation of the diagnostic techniques for Hu-Abs detection (immunofluorescence, immunodot/Western blot, and CBA) in serum and/or CSF.

Genomic and transcriptomic features of tumors (histological and immune infiltrate characteristics, transcriptomic profile, mutational status).

• Inclusion Criteria * :

  • Patient with neurological disorder
  • Patient with Hu antibody in sera or CSF

• Exclusion Criteria * :

  • Patient with no data
  • Patient without neurological disorder
  • Patient without Hu antibody in sera/CSF