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The objective of the study is to evaluate the impact of not reporting antibiotic susceptibility tests on antibiotic consumption for Enterococcus faecalis positive urine cultures in adult hospitalized patients. The secondary objectives are to evaluate the impact of this intervention on antibiotic prescription rates as well as on antibiotic consumption according to: patient gender, type of antibiotic therapy (probabilistic/documented) and diagnosis (urinary tract infection or colonization). It is hypothesized that antibiotic consumption is lower after the application of the absence of antibiotic susceptibility reporting compared to before.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Before group | Group of patients with a positive urine culture for Enterococcus faecalis before the procedure consisting of systematically performing an antibiotic susceptibility test. | ||
| After group | Group of patients with a positive urine culture for Enterococcus faecalis after the procedure consisting of systematically performing an antibiotic susceptibility test. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stop performing an antibiotic susceptibility test | Other | Intervention = Stop performing an antibiotic susceptibility test for enterococcus faecalis in urine cultures. It defines two groups : one before and one after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of positive urine culture for which antibiotic therapy was prescribed (%) | Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist |
| Measure | Description | Time Frame |
|---|---|---|
| Prescription rate of each antibiotic class/molecule (%) | Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist | |
| Proportion of urine cultures for which antibiotic therapy was prescribed (%) by type of antibiotic therapy. |
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Inclusion Criteria:
Exclusion Criteria:
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These are urine cultures taken from 2nd urine stream, by urinary catheter or via a suprapubic catheter and with a positive culture for monomicrobial Enterococcus faecalis with a bacteriuria threshold greater than or equal to 10^3. These urine cultures were performed between December 10, 2018 and December 10, 2020 in adults hospitalized at the Nancy University Hospital and present at least 72 hours after the validation of the antibiogram or the identification of the germ, excluding hospitalization or passage in hematology services, continuous care/intensive care, day hospitalization and consultation.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nancy University Hospital | Vandœuvre-lès-Nancy | 54511 | France |
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Type of antibiotic therapy = probabilistic or documented |
| Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist |
| Prescription rate of each antibiotic class/molecule (%) by type of antibiotic therapy. | Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist |
| Proportion of urine cultures for which antibiotic therapy was prescribed (%) by sex of patient | Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist |
| Prescription rate of each antibiotic class/molecule (%) by patient gender | Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist |
| Proportion of urine cultures for which antibiotic therapy was prescribed (%) by diagnosis | Diagnosis = UTI or UCC | Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist |
| Prescription rate of each antibiotic class/molecule (%) by diagnosis | Diagnosis = UTI or UCC | Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist |