The aim of this study is to assess the effect of different progesterone containing contraceptive methods on safety and endogenous progesterone level

Progestogen-only' contraceptives are presented as injections, implants, oral formulations, hormone-releasing intrauterine methods and emergency contraceptives. These substances could be used by females who are breastfeeding or have other contraindications to estrogen treatment, including those who are immediately postpartum, have thalassemia, sickle-cell disease, gallbladder disease, or currently experiencing thrombo-embolic disorders, valvular heart disease, ischemic heart disease.

Intrauterine, injectable methods and contraceptive implants named as long-acting reversible contraceptives (LARC) are the more efficient reversible contraceptive approaches are highly effective, longer-acting contraceptive methods levels.

Inclusion Criteria:

• 80 healthy fertile females
• 20-35 years
• With normal menstrual history
• Had at least one offspring after spontaneous pregnancy

Exclusion Criteria:

• Any disease affects uterus (uterine tumors fibroids, endometriosis, prolapse, or tuberculosis).
• Ovarian tumors
• submucous myoma
• irregular menstrual cycle
• past or family history of breast disease
• Diabetic patients,
• medication affecting reproductive or metabolic functions.
• endometrial thickness <7 mm on the secretory transformation day
• history of spontaneous abortions
• history of embryo transfer failure on over three occasions
• Patients had cortisol medications
• patients who received radiological treatment

Among patients attending Tanta University Hospitals

The data will be available upon reasonable request from the principal investigator

One year