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In this study, the effect of oxycodone combined with ultrasound-guided paravertebral nerve block on the postoperative analgesic effect of thoracoscopic lung cancer was investigated, and the effect and reasonable dose of oxycodone were explored, which provided a reference for the clinical multimodal analgesia after thoracoscopic lung cancer surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test group 1(OCA group) | Experimental |
| |
| Test group 2(OCB group) | Experimental |
| |
| Control group(SF group) | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxycodone 1mg/kg | Drug | Test group 1 (OCA group):oxycodone 1mg/kg + flurbiprofen 50mg + ondansetron 16mg + 0.9% normal saline diluted to 100ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| The main indicators were NRS scores at rest and cough at 24 h postoperatively. | NRS (numerical rating scale) is composed of 11 numbers from 0 to 10, and patients use 11 numbers from 0 to 10 to describe the intensity of pain, and the higher the number, the more severe the pain. | at 24h after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Time to double-lumen tracheal extraction | Time to double-lumen tracheal extraction | Within two hours after surgery |
| NRS score at rest and cough | NRS (numerical rating scale) is composed of 11 numbers from 0 to 10, and patients use 11 numbers from 0 to 10 to describe the intensity of pain, and the higher the number, the more severe the pain. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pengcai Shi, Chief physician | Contact | 13791126828 | shipc1997@163.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37844986 | Derived | Wang Y, Wu G, Liu Z, Wei X, Feng H, Su J, Shi P. Effect of oxycodone combined with ultrasound-guided thoracic paravertebral nerve block on postoperative analgesia in patients with lung cancer undergoing thoracoscopic surgery: protocol for a randomised controlled study. BMJ Open. 2023 Oct 16;13(10):e074416. doi: 10.1136/bmjopen-2023-074416. |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D010098 | Oxycodone |
| D017409 | Sufentanil |
| ID | Term |
|---|---|
| D003061 | Codeine |
| D009022 | Morphine Derivatives |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
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|
| Oxycodone 1.5mg/kg | Drug | Test group 2 (OCB group): oxycodone 1.5mg/kg + flurbiprofen 50mg + ondansetron 16mg + 0.9% normal saline diluted to 100ml. |
|
| Sufentanil | Drug | Control group (SF group): sufentanil 2ug/kg + flurbiprofen + ondansetron 16mg + 0.9% normal saline diluted to 100ml. |
|
| at 2h , 4h, 12h, 48h after surgery |
| sedation score (Ramsay sedation score) | The Ramsay sedation score is the most widely used sedation scoring criterion in clinical practice. It is divided into six levels, reflecting three levels of wakefulness and three levels of sleep. The higher the level, the deeper the level of sedation. | at 2 h , 4 h , 12 h ,24 h,48 h postoperatively |
| sufentanil consumption | sufentanil consumption | Within 48 hours after surgery |
| oxycodone consumption | oxycodone consumption | Within 48 hours after surgery |
| analgesic pump compressions | analgesic pump compressions | Within 48 hours after surgery |
| additional analgesic doses | additional analgesic doses | Within 48 hours after surgery |
| incidence of adverse reactions: nausea, vomiting, respiratory depression, dizziness, itchin | incidence of adverse reactions: nausea, vomiting, respiratory depression, dizziness, itchin | Within 48 hours after surgery |
| gastrointestinal recovery (exhaust time) | gastrointestinal recovery (exhaust time) | Within 48 hours after surgery |
| laboratory results of C-reactive protein 1 day before and after surgery | laboratory results of C-reactive protein 1 day before and after surgery | Within 48 hours after surgery |
| laboratory results of interleukin-6 laboratory test 1 day before and after surgery | laboratory results of interleukin-6 laboratory test 1 day before and after surgery | Within 48 hours after surgery |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D000470 |
| Alkaloids |
| D006571 | Heterocyclic Compounds |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |