Neuropathy and Anti-GFAP Antibodies

Study of the Consequences of Anti-GFAP Antibodies on the Peripheral Nervous System

Anti-Glial Fibrillary Acidic Protein (GFAP) are antibodies associated to inflammatory diseases of the central nervous system. The GFAP protein is highly expressed by astrocytes explaining these syndromes, but GFAP is also expressed by immature and non-myelinating Schwann cells. Thus, these antibodies could also lead to damages of the peripheral nervous system (PNS). Moreover, such damages have already been reported on small studies, and there is a need for larger cohorts.

The investigators will use the cohort of patients with neurological syndromes and anti-GFAP antibodies identified in the cerebrospinal fluid (CSF) of the "Reference center for paraneoplastic neurological syndromes and autoimmune encephalitis" to determine the frequency of the PNS involvement in these patients.

Inclusion Criteria:

• - Age > 18 years old
• Neurological symptoms
• Anti-GFAP antibodies identified in the CSF

Exclusion Criteria:

• - Uncomplete data in the medical records of patients